2-(4-methylphenyl)-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-6,7-dihydro-5H-benzo[a][7]annulene-8-carboxamide

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Chemical Name:2-(4-methylphenyl)-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-6,7-dihydro-5H-benzo[a][7]annulene-8-carboxamide
CAS No.:229005-52-1
Molecular Formula:C₃₂H₃₆N₂O₂
Molecular Weight:480.65
Hs Code.:

Synonyms:2-(4-methylphenyl)-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-6,7-dihydro-5H-benzo[a][7]annulene-8-carboxamide

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Chemical Property of 2-(4-methylphenyl)-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-6,7-dihydro-5H-benzo[a][7]annulene-8-carboxamide

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Technology Process of 2-(4-methylphenyl)-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-6,7-dihydro-5H-benzo[a][7]annulene-8-carboxamide

There total 34 articles about 2-(4-methylphenyl)-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-6,7-dihydro-5H-benzo[a][7]annulene-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 229007-09-4
4-[N-methyl-N-(tetrahydro-2H-pyran-4-yl)aminomethyl]aniline

: 3-p-tolyl-8,9-dihydro-7H-benzocycloheptene-6-carbonyl chloride

: 229005-52-1
2-(4-methylphenyl)-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-6,7-dihydro-5H-benzo[a][7]annulene-8-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm9906264

Reference yield: 90.0%

: 2-bromo-N-{4-[N-methyl-N-(tetrahydro-2H-pyran-4-yl)aminomethyl]phenyl}-6,7-dihydro-5H-benzo[7]annulene-8-carboxamide

: 5720-05-8
4-methylphenylboronic acid

: 229005-52-1
2-(4-methylphenyl)-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-6,7-dihydro-5H-benzo[a][7]annulene-8-carboxamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,2-dimethoxyethane; for 12h; Reagent/catalyst; Temperature; Solvent; Time; Schlenk technique; Inert atmosphere; Sealed tube; Reflux;
DOI:10.1039/c3ob41873a

Reference yield: 50.0%

: 229007-09-4
4-[N-methyl-N-(tetrahydro-2H-pyran-4-yl)aminomethyl]aniline

: 229006-88-6
2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid

: 229005-52-1
2-(4-methylphenyl)-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-6,7-dihydro-5H-benzo[a][7]annulene-8-carboxamide

Guidance literature:: 2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 0.666667h;

4-[N-methyl-N-(tetrahydro-2H-pyran-4-yl)aminomethyl]aniline; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1081/SCC-120037909