N-{(S)-2-Hydroxy-3-[2-(20-{2-[(S)-2-hydroxy-3-(isopropyl-methanesulfonyl-amino)-propoxy]-phenoxy}-icosyloxy)-phenoxy]-propyl}-N-isopropyl-methanesulfonamide

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Chemical Name:N-{(S)-2-Hydroxy-3-[2-(20-{2-[(S)-2-hydroxy-3-(isopropyl-methanesulfonyl-amino)-propoxy]-phenoxy}-icosyloxy)-phenoxy]-propyl}-N-isopropyl-methanesulfonamide
CAS No.:86955-62-6
Molecular Formula:C₄₆H₈₀N₂O₁₀S₂
Molecular Weight:885.281
Hs Code.:

N-{(S)-2-Hydroxy-3-[2-(20-{2-[(S)-2-hydroxy-3-(isopropyl-methanesulfonyl-amino)-propoxy]-phenoxy}-icosyloxy)-phenoxy]-propyl}-N-isopropyl-methanesulfonamide

Synonyms:N-{(S)-2-Hydroxy-3-[2-(20-{2-[(S)-2-hydroxy-3-(isopropyl-methanesulfonyl-amino)-propoxy]-phenoxy}-icosyloxy)-phenoxy]-propyl}-N-isopropyl-methanesulfonamide

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Chemical Property of N-{(S)-2-Hydroxy-3-[2-(20-{2-[(S)-2-hydroxy-3-(isopropyl-methanesulfonyl-amino)-propoxy]-phenoxy}-icosyloxy)-phenoxy]-propyl}-N-isopropyl-methanesulfonamide

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Technology Process of N-{(S)-2-Hydroxy-3-[2-(20-{2-[(S)-2-hydroxy-3-(isopropyl-methanesulfonyl-amino)-propoxy]-phenoxy}-icosyloxy)-phenoxy]-propyl}-N-isopropyl-methanesulfonamide

There total 5 articles about N-{(S)-2-Hydroxy-3-[2-(20-{2-[(S)-2-hydroxy-3-(isopropyl-methanesulfonyl-amino)-propoxy]-phenoxy}-icosyloxy)-phenoxy]-propyl}-N-isopropyl-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 14296-16-3
1,20-dibromoeicosane

: 72224-15-8
(2S)-1-(2-hydroxyphenoxy)-3-<(1-methylethyl)(methylsulfonyl)amino>-2-propanol

: 86955-62-6
N-{(S)-2-Hydroxy-3-[2-(20-{2-[(S)-2-hydroxy-3-(isopropyl-methanesulfonyl-amino)-propoxy]-phenoxy}-icosyloxy)-phenoxy]-propyl}-N-isopropyl-methanesulfonamide

Guidance literature:: With sodium hydroxide; In dimethyl sulfoxide; at 75 ℃; for 3h;
DOI:10.1021/jm00365a004

Reference yield:

: 72223-70-2
(4S)-2,2-dimethyl-4-<<(1-methylethyl)(methylsulfonyl)amino>methyl>-1,3-dioxolane

: 86955-62-6
N-{(S)-2-Hydroxy-3-[2-(20-{2-[(S)-2-hydroxy-3-(isopropyl-methanesulfonyl-amino)-propoxy]-phenoxy}-icosyloxy)-phenoxy]-propyl}-N-isopropyl-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 84.6 percent / Dowex₅₀W-8x ion-exchange resin (H⁺ form / aq. ethanol / 1.5 h / Heating

2: 22.8 g / pyridine / 5 h / -45 °C

3: 63 percent / NaOH / H₂O; dimethylsulfoxide / 25 h / 80 °C

4: 72 percent / 4.0 N NaOH / dimethylsulfoxide / 3 h / 75 °C

With pyridine; sodium hydroxide; Dowex₅₀W-8x ion-exchange resin (H⁺ form; In ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm00365a004

Reference yield:

: 72223-72-4
(2S)-3-<(1-methylethyl)(methylsulfonyl)amino>-1-<(methylsulfonyl)oxy>-2-propanol

: 86955-62-6
N-{(S)-2-Hydroxy-3-[2-(20-{2-[(S)-2-hydroxy-3-(isopropyl-methanesulfonyl-amino)-propoxy]-phenoxy}-icosyloxy)-phenoxy]-propyl}-N-isopropyl-methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / NaOH / H₂O; dimethylsulfoxide / 25 h / 80 °C

2: 72 percent / 4.0 N NaOH / dimethylsulfoxide / 3 h / 75 °C

With sodium hydroxide; In water; dimethyl sulfoxide;
DOI:10.1021/jm00365a004