Technology Process of (2S,3S,4R)-1,2-epoxy-3-hydroxy-4-azide-5-cyclohexylpentane
There total 5 articles about (2S,3S,4R)-1,2-epoxy-3-hydroxy-4-azide-5-cyclohexylpentane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium;
In
dichloromethane;
Ambient temperature;
DOI:10.1016/0040-4020(94)01107-B
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) L-(+)-DIPT, TBHP, 4 Angstroem molecule sieves, Ti(OiPr)4, 2.) Et3N, DMAP / 1.) CH2Cl2, -20 deg C, 10 d, 2.) CH2Cl2, -10 deg C, 24 h
2: 81 percent / 10percent mol CuI, cyclohexyl chloride / tetrahydrofuran / -10 °C
3: 75 percent / pyridine / CH2Cl2 / Ambient temperature
4: 1.) NaN3, 2.) 5percent aq. HCl / 1.) DMF, 90 deg C, 12 h, 2.) DMF, 15 min
5: 68 percent / VO(acac)2, TBHP / CH2Cl2 / Ambient temperature
With
pyridine; titanium(IV) isopropylate; hydrogenchloride; tert.-butylhydroperoxide; dmap; copper(l) iodide; sodium azide; bis(acetylacetonate)oxovanadium; L-(+)-diisopropyl tartrate; cyclohexyl chloride; 4 A molecular sieve; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/0040-4020(94)01107-B
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 75 percent / pyridine / CH2Cl2 / Ambient temperature
2: 1.) NaN3, 2.) 5percent aq. HCl / 1.) DMF, 90 deg C, 12 h, 2.) DMF, 15 min
3: 68 percent / VO(acac)2, TBHP / CH2Cl2 / Ambient temperature
With
pyridine; hydrogenchloride; tert.-butylhydroperoxide; sodium azide; bis(acetylacetonate)oxovanadium;
In
dichloromethane;
DOI:10.1016/0040-4020(94)01107-B
