5'-O-(4,4'-dimethoxytrityl)-3'-O-[(diisopropylamino)(2-cyanoethoxy)phosphino]-3-hydroxy-1,N²-benzetheno-2'-deoxyguanosine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(diisopropylamino)(2-cyanoethoxy)phosphino]-3-hydroxy-1,N²-benzetheno-2'-deoxyguanosine
• CAS No.: 185518-95-0
• Molecular Formula: C₄₆H₅₀N₇O₈P
• Molecular Weight: 859.919

Synonyms:5'-O-(4,4'-dimethoxytrityl)-3'-O-[(diisopropylamino)(2-cyanoethoxy)phosphino]-3-hydroxy-1,N²-benzetheno-2'-deoxyguanosine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(diisopropylamino)(2-cyanoethoxy)phosphino]-3-hydroxy-1,N²-benzetheno-2'-deoxyguanosine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(diisopropylamino)(2-cyanoethoxy)phosphino]-3-hydroxy-1,N²-benzetheno-2'-deoxyguanosine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(diisopropylamino)(2-cyanoethoxy)phosphino]-3-hydroxy-1,N²-benzetheno-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 5'-O-(4,4'-dimethoxytrityl)-3-hydroxy-1,N2-benzetheno-2'-deoxyguanosine (185518-94-9) → 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(diisopropylamino)(2-cyanoethoxy)phosphino]-3-hydroxy-1,N2-benzetheno-2'-deoxyguanosine (185518-95-0)

Guidance literature:

With triethylamine; In dichloromethane; at -72 - 20 ℃; for 1.1h;

DOI:10.1021/tx960168r

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(diisopropylamino)(2-cyanoethoxy)phosphino]-3-hydroxy-1,N2-benzetheno-2'-deoxyguanosine (185518-95-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / pyridine / 6 h / 20 °C

2: 69 percent / Et₃N / CH₂Cl₂ / 1.1 h / -72 - 20 °C

With pyridine; triethylamine; In dichloromethane;

DOI:10.1021/tx960168r

Reference yield:

2'-Deoxyguanosine (961-07-9) → 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(diisopropylamino)(2-cyanoethoxy)phosphino]-3-hydroxy-1,N2-benzetheno-2'-deoxyguanosine (185518-95-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 28 percent / potassium carbonate / dimethylsulfoxide / 22 h / 20 °C

2: 78 percent / pyridine / 6 h / 20 °C

3: 69 percent / Et₃N / CH₂Cl₂ / 1.1 h / -72 - 20 °C

With pyridine; potassium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/tx960168r

upstream raw materials:

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

5'-O-(4,4'-dimethoxytrityl)-3-hydroxy-1,N²-benzetheno-2'-deoxyguanosine

4,4'-dimethoxytrityl chloride

2'-Deoxyguanosine

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