tert-butyl (1R,3R)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-1-p-tolylbutylcarbamate

Base Information

Chemical Name:tert-butyl (1R,3R)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-1-p-tolylbutylcarbamate
CAS No.:1616379-64-6
Molecular Formula:C₂₂H₃₉NO₄Si
Molecular Weight:409.641
Hs Code.:

Synonyms:tert-butyl (1R,3R)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-1-p-tolylbutylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (1R,3R)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-1-p-tolylbutylcarbamate

Chemical Property:

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Technology Process of tert-butyl (1R,3R)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-1-p-tolylbutylcarbamate

There total 5 articles about tert-butyl (1R,3R)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-1-p-tolylbutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: C₁₇H₃₁NO₂Si

: 1616379-64-6
tert-butyl (1R,3R)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-1-p-tolylbutylcarbamate

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/j.tet.2014.05.037

Reference yield:

: 1467751-07-0
(R,E)-N-((R)-3,4-bis(tert-butyldimethylsilyloxy)butylidene)-2-methylpropane-2-sulfinamide

: 1616379-64-6
tert-butyl (1R,3R)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-1-p-tolylbutylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane; tetrahydrofuran / 12 h / -78 - 20 °C

2: hydrogenchloride / ethanol; 1,4-dioxane / 0.5 h / 0 °C

3: triethylamine / dichloromethane

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.tet.2014.05.037

Reference yield:

: 503604-05-5
(+)-(R)-methyl 3,4-bis((tert-butyldimethylsilyl)oxy)butanoate

: 1616379-64-6
tert-butyl (1R,3R)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-1-p-tolylbutylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / toluene; hexane / 0.33 h / -78 °C

2: copper(II) sulfate; pyridinium p-toluenesulfonate / dichloromethane / 19 h

3: dichloromethane; tetrahydrofuran / 12 h / -78 - 20 °C

4: hydrogenchloride / ethanol; 1,4-dioxane / 0.5 h / 0 °C

5: triethylamine / dichloromethane

With hydrogenchloride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; copper(II) sulfate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; toluene;
DOI:10.1016/j.tet.2014.05.037