[5,6,7,8-tetrahydro-4-oxo-5-[2-(pyridin-4-yl)ethyl]-4H-pyrazolo[1,5-a][1,4]diazepin-2-yl]carboxylic acid

Base Information

• Chemical Name: [5,6,7,8-tetrahydro-4-oxo-5-[2-(pyridin-4-yl)ethyl]-4H-pyrazolo[1,5-a][1,4]diazepin-2-yl]carboxylic acid
• CAS No.: 1026409-99-3
• Molecular Formula: C₁₅H₁₆N₄O₃
• Molecular Weight: 300.317
• Mol file: 1026409-99-3.mol

Synonyms:[5,6,7,8-tetrahydro-4-oxo-5-[2-(pyridin-4-yl)ethyl]-4H-pyrazolo[1,5-a][1,4]diazepin-2-yl]carboxylic acid

Chemical Property of [5,6,7,8-tetrahydro-4-oxo-5-[2-(pyridin-4-yl)ethyl]-4H-pyrazolo[1,5-a][1,4]diazepin-2-yl]carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [5,6,7,8-tetrahydro-4-oxo-5-[2-(pyridin-4-yl)ethyl]-4H-pyrazolo[1,5-a][1,4]diazepin-2-yl]carboxylic acid

There total 1 articles about [5,6,7,8-tetrahydro-4-oxo-5-[2-(pyridin-4-yl)ethyl]-4H-pyrazolo[1,5-a][1,4]diazepin-2-yl]carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-vinylpyridine (100-43-6,329041-72-7) → [5,6,7,8-tetrahydro-4-oxo-5-[2-(pyridin-4-yl)ethyl]-4H-pyrazolo[1,5-a][1,4]diazepin-2-yl]carboxylic acid (1026409-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / t-BuOH; NMO / tetrahydrofuran

2: NaOH / H₂O / 1 h / 50 °C

With sodium hydroxide; N-methyl-2-indolinone; tert-butyl alcohol; In tetrahydrofuran; water; 1: Alkylation / 2: Hydrolysis;

DOI:10.1021/jo990644t

Reference yield:

[5,6,7,8-tetrahydro-4-oxo-5-[2-(pyridin-4-yl)ethyl]-4H-pyrazolo[1,5-a][1,4]diazepin-2-yl]carboxylic acid (1026409-99-3) → 2(S)-[(p-toluenesulfonyl)amino]-3-[[[5,6,7,8-tetrahydro-4-oxo-5-[2-(pyridin-4-yl)ethyl]-4H-pyrazolo[1,5-a][1,4]diazepin-2-yl]carbonyl]amino]propionic acid

Guidance literature:

Multi-step reaction with 2 steps

1: HOBT; EDC / acetonitrile; H₂O

2: 84 percent / H₂; aq. HCl / Pd/C / H₂O / 30 h / 70 °C / 5171.48 Torr

With hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In water; acetonitrile; 1: Substitution / 2: Hydrogenolysis;

DOI:10.1021/jo990644t

Reference yield:

[5,6,7,8-tetrahydro-4-oxo-5-[2-(pyridin-4-yl)ethyl]-4H-pyrazolo[1,5-a][1,4]diazepin-2-yl]carboxylic acid (1026409-99-3) + 2-(S)-(p-toluenesulfonylamino)-β-alanine benzyl ester tosylate → 2(S)-[(p-toluenesulfonyl)amino]-3-[[[5,6,7,8-tetrahydro-4-oxo-5-[2-(pyridin-4-yl)ethyl]-4H-pyrazolo[1,5-a][1,4]diazepin-2-yl]carbonyl]amino]propionic acid benzyl ester (251553-60-3)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In water; acetonitrile;

DOI:10.1021/jo990644t

upstream raw materials:

4-vinylpyridine

Downstream raw materials:

2(S)-[(p-toluenesulfonyl)amino]-3-[[[5,6,7,8-tetrahydro-4-oxo-5-[2-(pyridin-4-yl)ethyl]-4H-pyrazolo[1,5-a][1,4]diazepin-2-yl]carbonyl]amino]propionic acid benzyl ester