Technology Process of (3aR,6S,6aS)-4-benzoyl-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2-carboxylic acid tert-butyl ester
There total 11 articles about (3aR,6S,6aS)-4-benzoyl-1-[(2S)-2-(4-tert-butylbenzoylamino)-4-methylpentanoyl]-6-hydroxyhexahydropyrrolo[3,2-c]pyrazole-2-carboxylic acid tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 14 steps
1: 90 percent / LiBH4 / methanol; tetrahydrofuran
2: Et3N / CH2Cl2
3: sodium azide / dimethylformamide / 110 °C
4: 74 percent / PPh3; H2O / dioxane / 50 °C
5: 36 percent / CH2Cl2
6: 79 percent / Et3N / methanol / 60 °C
7: 97 percent / Pd(PPh3)4; PhSiH3 / CH2Cl2
8: 63 percent / dimethylformamide
9: 96 percent / Pd(PPh3)4; PhSiH3 / CH2Cl2
10: 84 percent / HBTU; HOBT; NMM / dimethylformamide
11: 62 percent / m-chloroperoxybenzoic acid / CH2Cl2
12: 42 percent / potassium carbonate / acetonitrile / 60 °C
13: H2 / Pd/C / ethanol
14: dimethylformamide
With
4-methyl-morpholine; lithium borohydride; tetrakis(triphenylphosphine) palladium(0); sodium azide; phenylsilane; water; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.01.022
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 74 percent / PPh3; H2O / dioxane / 50 °C
2: 36 percent / CH2Cl2
3: 79 percent / Et3N / methanol / 60 °C
4: 97 percent / Pd(PPh3)4; PhSiH3 / CH2Cl2
5: 63 percent / dimethylformamide
6: 96 percent / Pd(PPh3)4; PhSiH3 / CH2Cl2
7: 84 percent / HBTU; HOBT; NMM / dimethylformamide
8: 62 percent / m-chloroperoxybenzoic acid / CH2Cl2
9: 42 percent / potassium carbonate / acetonitrile / 60 °C
10: H2 / Pd/C / ethanol
11: dimethylformamide
With
4-methyl-morpholine; tetrakis(triphenylphosphine) palladium(0); phenylsilane; water; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
palladium on activated charcoal;
In
1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.01.022
- Guidance literature:
-
Multi-step reaction with 12 steps
1: sodium azide / dimethylformamide / 110 °C
2: 74 percent / PPh3; H2O / dioxane / 50 °C
3: 36 percent / CH2Cl2
4: 79 percent / Et3N / methanol / 60 °C
5: 97 percent / Pd(PPh3)4; PhSiH3 / CH2Cl2
6: 63 percent / dimethylformamide
7: 96 percent / Pd(PPh3)4; PhSiH3 / CH2Cl2
8: 84 percent / HBTU; HOBT; NMM / dimethylformamide
9: 62 percent / m-chloroperoxybenzoic acid / CH2Cl2
10: 42 percent / potassium carbonate / acetonitrile / 60 °C
11: H2 / Pd/C / ethanol
12: dimethylformamide
With
4-methyl-morpholine; tetrakis(triphenylphosphine) palladium(0); sodium azide; phenylsilane; water; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
palladium on activated charcoal;
In
1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2005.01.022
