1-methyl-4-(3'-amino-4',5'-dimethoxyphenyl)-5-(3''-fluoro-4-methoxyphenyl)imidazole

Base Information

Chemical Name:1-methyl-4-(3'-amino-4',5'-dimethoxyphenyl)-5-(3''-fluoro-4-methoxyphenyl)imidazole
CAS No.:1245716-28-2
Molecular Formula:C₁₉H₂₀FN₃O₃
Molecular Weight:357.385
Hs Code.:

Synonyms:1-methyl-4-(3'-amino-4',5'-dimethoxyphenyl)-5-(3''-fluoro-4-methoxyphenyl)imidazole

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Chemical Property of 1-methyl-4-(3'-amino-4',5'-dimethoxyphenyl)-5-(3''-fluoro-4-methoxyphenyl)imidazole

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Technology Process of 1-methyl-4-(3'-amino-4',5'-dimethoxyphenyl)-5-(3''-fluoro-4-methoxyphenyl)imidazole

There total 3 articles about 1-methyl-4-(3'-amino-4',5'-dimethoxyphenyl)-5-(3''-fluoro-4-methoxyphenyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1245716-22-6
1-methyl-4-(3',4'-dimethoxy-5'-nitrophenyl)-5-(3''-fluoro-4''-methoxyphenyl)imidazole

: 1245716-28-2
1-methyl-4-(3'-amino-4',5'-dimethoxyphenyl)-5-(3''-fluoro-4-methoxyphenyl)imidazole

Guidance literature:: With 5% Pd(II)/C(eggshell); ammonium formate; In methanol; for 2h; Reflux;
DOI:10.1021/jm100345r

Reference yield:

: 1345961-99-0
3,4-dimethoxy-5-nitrophenyl(tosyl)methyl isocyanide

: 1245716-28-2
1-methyl-4-(3'-amino-4',5'-dimethoxyphenyl)-5-(3''-fluoro-4-methoxyphenyl)imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / ethanol / 2 h / Reflux

1.2: 3 h / Reflux

2.1: ammonium formate / 5%-palladium/activated carbon / methanol / 2 h / Reflux

With ammonium formate; acetic acid; 5%-palladium/activated carbon; In methanol; ethanol;

Reference yield:

: 1245716-03-3
N-[(toluene-4-sulfonyl)-(3,4-dimethoxy-5-nitrophenyl)methyl]formamide

: 1245716-28-2
1-methyl-4-(3'-amino-4',5'-dimethoxyphenyl)-5-(3''-fluoro-4-methoxyphenyl)imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; trichlorophosphate / 1,2-dimethoxyethane / -10 - -5 °C

2.1: acetic acid / ethanol / 2 h / Reflux

2.2: 3 h / Reflux

3.1: ammonium formate / 5%-palladium/activated carbon / methanol / 2 h / Reflux

With ammonium formate; acetic acid; triethylamine; trichlorophosphate; 5%-palladium/activated carbon; In methanol; 1,2-dimethoxyethane; ethanol;