3-[(4-METHOXYPHENYL)METHOXY]PYRIDINE-5-BORONIC ACID PINACOL ESTER

Base Information

• Chemical Name: 3-[(4-METHOXYPHENYL)METHOXY]PYRIDINE-5-BORONIC ACID PINACOL ESTER
• CAS No.: 956034-20-1
• Molecular Formula: C₁₉H₂₄BNO₄
• Molecular Weight: 341.215
• Mol file: 956034-20-1.mol

Synonyms:3-(4-methoxy-benzyloxy)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine

Chemical Property of 3-[(4-METHOXYPHENYL)METHOXY]PYRIDINE-5-BORONIC ACID PINACOL ESTER

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(4-METHOXYPHENYL)METHOXY]PYRIDINE-5-BORONIC ACID PINACOL ESTER

There total 1 articles about 3-[(4-METHOXYPHENYL)METHOXY]PYRIDINE-5-BORONIC ACID PINACOL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dimethyl-2,3-butane diol (76-09-5) + (5-((4-methoxybenzyl)oxy)pyridin-3-yl)boronic acid → 3-(4-methoxy-benzyloxy)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine (956034-20-1)

Guidance literature:

In toluene; for 4h; Heating / reflux;

Reference yield:

3-(4-methoxy-benzyloxy)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine (956034-20-1) + tert-butyl-3-iodoazetidine-1-carboxylate (254454-54-1) → tert-butyl 2-(5-((4-methoxybenzyl)oxy)pyridin-3-yl)azetidine-1-carboxylate + tert-butyl 3-(5-((4-methoxybenzyl)oxy)pyridin-3-yl)azetidine-1-carboxylate

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 60 ℃; for 24h; Overall yield = 62 %; Overall yield = 115 mg; regioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201600470

upstream raw materials:

2,3-dimethyl-2,3-butane diol