(2S,4R)-4-benzoyloxy-2-(4-ethoxycarbonylthiazol-2-yl)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

Base Information

Chemical Name:(2S,4R)-4-benzoyloxy-2-(4-ethoxycarbonylthiazol-2-yl)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine
CAS No.:496048-62-5
Molecular Formula:C₂₅H₂₃N₃O₈S
Molecular Weight:525.539
Hs Code.:

Synonyms:(2S,4R)-4-benzoyloxy-2-(4-ethoxycarbonylthiazol-2-yl)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

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Chemical Property of (2S,4R)-4-benzoyloxy-2-(4-ethoxycarbonylthiazol-2-yl)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

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Technology Process of (2S,4R)-4-benzoyloxy-2-(4-ethoxycarbonylthiazol-2-yl)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

There total 2 articles about (2S,4R)-4-benzoyloxy-2-(4-ethoxycarbonylthiazol-2-yl)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.2%

: 70-23-5
ethyl Bromopyruvate

: 496048-61-4
(2S,4R)-4-benzoyloxy-2-thiocarbamoyl-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

: 496048-62-5
(2S,4R)-4-benzoyloxy-2-(4-ethoxycarbonylthiazol-2-yl)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: In ethanol; at 20 ℃; for 20h;
DOI:10.1016/S0223-5234(02)01397-1

Reference yield:

: (2S,4R)-4-Benzoyloxy-2-carbamoyl-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester

: 496048-62-5
(2S,4R)-4-benzoyloxy-2-(4-ethoxycarbonylthiazol-2-yl)-1-(p-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 94.7 percent / Lawesson's reagent / tetrahydrofuran / 2 h / Heating

2: 89.2 percent / ethanol / 20 h / 20 °C

With Lawessons reagent; In tetrahydrofuran; ethanol;
DOI:10.1016/S0223-5234(02)01397-1