8-oxo-9-(3,4,5-trimethoxyphenyl)-6,8-dihydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carbaldehyde

Base Information

Chemical Name:8-oxo-9-(3,4,5-trimethoxyphenyl)-6,8-dihydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carbaldehyde
CAS No.:1002130-61-1
Molecular Formula:C₂₃H₁₈O₈
Molecular Weight:422.391
Hs Code.:

Synonyms:8-oxo-9-(3,4,5-trimethoxyphenyl)-6,8-dihydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carbaldehyde

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Chemical Property of 8-oxo-9-(3,4,5-trimethoxyphenyl)-6,8-dihydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carbaldehyde

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Technology Process of 8-oxo-9-(3,4,5-trimethoxyphenyl)-6,8-dihydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carbaldehyde

There total 6 articles about 8-oxo-9-(3,4,5-trimethoxyphenyl)-6,8-dihydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1002130-85-9
9-hydroxymethyl-5-(3,4,5-trimethoxyphenyl)-8H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

: 1002130-61-1
8-oxo-9-(3,4,5-trimethoxyphenyl)-6,8-dihydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carbaldehyde

Guidance literature:: With 4 A molecular sieve; pyridinium chlorochromate; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1002/adsc.200600587

Reference yield:

: 1002130-82-6
3-(N-methoxy-N-methylcarbamoyl)prop-2-ynyl 3-(3,4,5-trimethoxyphenyl)propiolate

: 1002130-61-1
8-oxo-9-(3,4,5-trimethoxyphenyl)-6,8-dihydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: 71 percent / CsF; P(o-tol)3 / Pd₂(dba)3*CHCl₃ / acetonitrile / 40 h / 20 °C

2.1: 85 percent / NaH / CH₂Cl₂ / 24 h / 20 °C

3.1: DIBAL-H / CH₂Cl₂; toluene / 2 h / -78 °C

3.2: 61 percent / aq. potassium sodium tartrate / CH₂Cl₂; methanol / -78 - 20 °C

4.1: 92 percent / NaBH₄ / methanol; tetrahydrofuran / 16 h / 0 °C

5.1: 98 percent / molecular sieves 4 Angstroem; PCC / CH₂Cl₂ / 2 h / 0 °C

With sodium tetrahydroborate; 4 A molecular sieve; sodium hydride; diisobutylaluminium hydride; cesium fluoride; tris-(o-tolyl)phosphine; pyridinium chlorochromate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1002/adsc.200600587

Reference yield:

: 717903-52-1
6-(trimethylsilyl)benzo[d][1,3]dioxol-5-yl triflate

: 1002130-61-1
8-oxo-9-(3,4,5-trimethoxyphenyl)-6,8-dihydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: 71 percent / CsF; P(o-tol)3 / Pd₂(dba)3*CHCl₃ / acetonitrile / 40 h / 20 °C

2.1: 85 percent / NaH / CH₂Cl₂ / 24 h / 20 °C

3.1: DIBAL-H / CH₂Cl₂; toluene / 2 h / -78 °C

3.2: 61 percent / aq. potassium sodium tartrate / CH₂Cl₂; methanol / -78 - 20 °C

4.1: 92 percent / NaBH₄ / methanol; tetrahydrofuran / 16 h / 0 °C

5.1: 98 percent / molecular sieves 4 Angstroem; PCC / CH₂Cl₂ / 2 h / 0 °C

With sodium tetrahydroborate; 4 A molecular sieve; sodium hydride; diisobutylaluminium hydride; cesium fluoride; tris-(o-tolyl)phosphine; pyridinium chlorochromate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1002/adsc.200600587