5H-Cyclopenta[b]pyridin-5-amine,6,7-dihydro-(9CI)

Base Information

• Chemical Name: 5H-Cyclopenta[b]pyridin-5-amine,6,7-dihydro-(9CI)
• CAS No.: 535935-84-3
• Molecular Formula: C₈H₁₀N₂
• Molecular Weight: 134.181
• Mol file: 535935-84-3.mol

Synonyms:6,7-Dihydro-5H-cyclopenta[beta]pyridin-5-amine;[6,7-Dihydro-5H-[1]pyrindin-5-yl]amine;

Chemical Property of 5H-Cyclopenta[b]pyridin-5-amine,6,7-dihydro-(9CI)

Chemical Property:

• Vapor Pressure: 0.05mmHg at 25°C
• Refractive Index: 1.586
• Boiling Point: 235.461 °C at 760 mmHg
• Flash Point: 119.197 °C
• PSA: 38.91000
• Density: 1.125 g/cm³
• LogP: 1.72790
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

6,7-Dihydro-5H-cyclopenta[b]pyridin-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5H-Cyclopenta[b]pyridin-5-amine,6,7-dihydro-(9CI)

There total 2 articles about 5H-Cyclopenta[b]pyridin-5-amine,6,7-dihydro-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

nickel (II) chloride hexahydrate + (5Z)-6,7-dihydro-5H-cyclopenta[b]pyridin-5-one oxime (535935-83-2) → 6,7-dihydro-5H-cyclopenta[b]pyridin-5-amine (535935-84-3)

Guidance literature:

With ammonium hydroxide; sodium borohydrid; In methanol;

Reference yield:

6,7-dihydro-[1]pyrindin-5-one O-methyl-oxime (1071727-80-4) → 6,7-dihydro-5H-cyclopenta[b]pyridin-5-amine (535935-84-3)

Guidance literature:

With ammonia; hydrogen; palladium on activated charcoal; In methanol; at 50 ℃; for 16h; under 3102.97 Torr;

DOI:10.1021/jm701007g

upstream raw materials:

(5Z)-6,7-dihydro-5H-cyclopenta[b]pyridin-5-one oxime

6,7-dihydro-[1]pyrindin-5-one O-methyl-oxime

Refernces

• 1、 -. "SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS". Page/Page column 33. . Retrieved 2008/12/04.