methyl-[4-oxo-2-(2-oxo-pyrrolidin-1-yl)-1,4,5,6-tetrahydro-pyrimidin-5-yl]-carbamic acid benzyl ester

Base Information

Chemical Name:methyl-[4-oxo-2-(2-oxo-pyrrolidin-1-yl)-1,4,5,6-tetrahydro-pyrimidin-5-yl]-carbamic acid benzyl ester
CAS No.:554412-86-1
Molecular Formula:C₁₇H₂₀N₄O₄
Molecular Weight:344.37
Hs Code.:

Synonyms:methyl-[4-oxo-2-(2-oxo-pyrrolidin-1-yl)-1,4,5,6-tetrahydro-pyrimidin-5-yl]-carbamic acid benzyl ester

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Chemical Property of methyl-[4-oxo-2-(2-oxo-pyrrolidin-1-yl)-1,4,5,6-tetrahydro-pyrimidin-5-yl]-carbamic acid benzyl ester

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Technology Process of methyl-[4-oxo-2-(2-oxo-pyrrolidin-1-yl)-1,4,5,6-tetrahydro-pyrimidin-5-yl]-carbamic acid benzyl ester

There total 5 articles about methyl-[4-oxo-2-(2-oxo-pyrrolidin-1-yl)-1,4,5,6-tetrahydro-pyrimidin-5-yl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 4-[5-(benzyloxycarbonyl-methyl-amino)-4-oxo-1,4,5,6-tetrahydro-pyrimidin-2-ylamino]-butyric acid

: 554412-86-1
methyl-[4-oxo-2-(2-oxo-pyrrolidin-1-yl)-1,4,5,6-tetrahydro-pyrimidin-5-yl]-carbamic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)00226-0

Reference yield:

: 56776-33-1
2-(Benzyloxycarbonyl-methyl-amino)-acrylic acid methyl ester

: 554412-86-1
methyl-[4-oxo-2-(2-oxo-pyrrolidin-1-yl)-1,4,5,6-tetrahydro-pyrimidin-5-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / acetonitrile / 20 °C

2: acetonitrile

3: 75 percent / iPr₂EtN / acetonitrile; methanol / 20 °C

4: TFA / CH₂Cl₂

5: 66 percent / HOBt; EDC / dimethylformamide

With potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: Michael addition;
DOI:10.1016/S0040-4039(03)00226-0

Reference yield:

: 554412-64-5
methyl-(2-methylsulfanyl-4-oxo-1,4,5,6-tetrahydro-pyrimidin-5-yl)-carbamic acid benzyl ester

: 554412-86-1
methyl-[4-oxo-2-(2-oxo-pyrrolidin-1-yl)-1,4,5,6-tetrahydro-pyrimidin-5-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile

2: 75 percent / iPr₂EtN / acetonitrile; methanol / 20 °C

3: TFA / CH₂Cl₂

4: 66 percent / HOBt; EDC / dimethylformamide

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(03)00226-0