Technology Process of C28H24ClFN6O2
There total 5 articles about C28H24ClFN6O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; trifluoroacetic acid;
In
tetrahydrofuran;
for 2h;
Inert atmosphere;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 40 °C
2: sodium hydroxide / methanol; water; tetrahydrofuran / 12 h / 20 °C
3: pyridine; thionyl chloride / N,N-dimethyl-formamide / 70 - 75 °C
4: triethylamine / dichloromethane / 3 h / 5 °C / Cooling with ice
5: sodium tetrahydroborate; trifluoroacetic acid / tetrahydrofuran / 2 h / Inert atmosphere; Reflux
With
pyridine; sodium tetrahydroborate; thionyl chloride; potassium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydroxide / methanol; water; tetrahydrofuran / 12 h / 20 °C
2: pyridine; thionyl chloride / N,N-dimethyl-formamide / 70 - 75 °C
3: triethylamine / dichloromethane / 3 h / 5 °C / Cooling with ice
4: sodium tetrahydroborate; trifluoroacetic acid / tetrahydrofuran / 2 h / Inert atmosphere; Reflux
With
pyridine; sodium tetrahydroborate; thionyl chloride; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
