N-((1S,3S)-3-hydroxy-1,3-diphenylpropyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-((1S,3S)-3-hydroxy-1,3-diphenylpropyl)-4-methylbenzenesulfonamide
CAS No.:1106719-36-1
Molecular Formula:C₂₂H₂₃NO₃S
Molecular Weight:381.496
Hs Code.:

Synonyms:N-((1S,3S)-3-hydroxy-1,3-diphenylpropyl)-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1S,3S)-3-hydroxy-1,3-diphenylpropyl)-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-((1S,3S)-3-hydroxy-1,3-diphenylpropyl)-4-methylbenzenesulfonamide

There total 7 articles about N-((1S,3S)-3-hydroxy-1,3-diphenylpropyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 1106719-36-1
N-((1S,3S)-3-hydroxy-1,3-diphenylpropyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: (R)-3,3'-di(4-tert-butylphenyl)(1,1'-binaphthyl)-2,2'-disulfonic acid; magnesium sulfate / monoethylene glycol diethyl ether / 5 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

2.2: 5 h / 0 - 80 °C

3.1: caesium carbonate / methanol; tetrahydrofuran / 12 h / 60 °C

4.1: 2-(diphenylphosphino)pyridine; azodicarboxylic acid bis(2-methoxyethyl) ester / tetrahydrofuran / 3 h / 20 °C

5.1: molybdenum hexacarbonyl; triethylamine / water; acetonitrile / 12 h / 80 °C

With azodicarboxylic acid bis(2-methoxyethyl) ester; 2-(diphenylphosphino)pyridine; (R)-3,3'-di(4-tert-butylphenyl)(1,1'-binaphthyl)-2,2'-disulfonic acid; sodium hydride; magnesium sulfate; caesium carbonate; triethylamine; molybdenum hexacarbonyl; In tetrahydrofuran; methanol; monoethylene glycol diethyl ether; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; 4.1: |Mitsunobu Displacement;
DOI:10.1021/jacs.7b04795

Reference yield:

: 150884-50-7
benzaldehyde N-boc imine

: 1106719-36-1
N-((1S,3S)-3-hydroxy-1,3-diphenylpropyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: (R)-3,3'-di(4-tert-butylphenyl)(1,1'-binaphthyl)-2,2'-disulfonic acid; magnesium sulfate / monoethylene glycol diethyl ether / 5 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

2.2: 5 h / 0 - 80 °C

3.1: caesium carbonate / methanol; tetrahydrofuran / 12 h / 60 °C

4.1: 2-(diphenylphosphino)pyridine; azodicarboxylic acid bis(2-methoxyethyl) ester / tetrahydrofuran / 3 h / 20 °C

5.1: molybdenum hexacarbonyl; triethylamine / water; acetonitrile / 12 h / 80 °C

With azodicarboxylic acid bis(2-methoxyethyl) ester; 2-(diphenylphosphino)pyridine; (R)-3,3'-di(4-tert-butylphenyl)(1,1'-binaphthyl)-2,2'-disulfonic acid; sodium hydride; magnesium sulfate; caesium carbonate; triethylamine; molybdenum hexacarbonyl; In tetrahydrofuran; methanol; monoethylene glycol diethyl ether; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; 4.1: |Mitsunobu Displacement;
DOI:10.1021/jacs.7b04795