(S)-3-AMINOTETRAHYDROFURAN-3-CARBOXYLIC ACID

Base Information

• Chemical Name: (S)-3-AMINOTETRAHYDROFURAN-3-CARBOXYLIC ACID
• CAS No.: 114715-53-6
• Molecular Formula: C₅H₉NO₂S
• Molecular Weight: 147.198
• Mol file: 114715-53-6.mol

Synonyms:(S)-3-AMINOTETRAHYDROFURAN-3-CARBOXYLIC ACID;3-Thiophenecarboxylicacid,3-aminotetrahydro-,(S)-(9CI)

Chemical Property of (S)-3-AMINOTETRAHYDROFURAN-3-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 4.56E-05mmHg at 25°C
• Boiling Point: 325.7°C at 760 mmHg
• Flash Point: 150.8°C
• PSA: 72.55000
• Density: 1.382
• LogP: -0.11090

Purity/Quality:

98%min ^*data from raw suppliers

(S)-3-Aminotetrahydrofuran-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-AMINOTETRAHYDROFURAN-3-CARBOXYLIC ACID

There total 5 articles about (S)-3-AMINOTETRAHYDROFURAN-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl tetrahydrothiophene-3,3-dicarboxylate (113417-95-1) → (-)-3-aminotetrahydrothiophene-3-carboxylic acid (114715-53-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / pig liver esterase / 4 h / 25 °C / 0.1 M phosphate buffer (pH 8.0)

2: ClCO₂Et, Et₃N / acetone / 1 h / 0 °C

3: sodium azide / H₂O / 1 h / 0 °C

4: benzene / 3 h / Heating

5: 20percent HCl / 2 h / Heating

With hydrogenchloride; sodium azide; pig liver esterase; chloroformic acid ethyl ester; triethylamine; In water; acetone; benzene;

DOI:10.1248/cpb.35.3845

Reference yield:

(S)-3-Chlorocarbonyl-tetrahydro-thiophene-3-carboxylic acid ethyl ester → (-)-3-aminotetrahydrothiophene-3-carboxylic acid (114715-53-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / H₂O / 1 h / 0 °C

2: benzene / 3 h / Heating

3: 20percent HCl / 2 h / Heating

With hydrogenchloride; sodium azide; In water; benzene;

DOI:10.1248/cpb.35.3845

Reference yield:

(-)-3-ethoxycarbonyltetrahydrothiophene-3-carboxylic acid (113417-96-2) → (-)-3-aminotetrahydrothiophene-3-carboxylic acid (114715-53-6)

Guidance literature:

Multi-step reaction with 4 steps

1: ClCO₂Et, Et₃N / acetone / 1 h / 0 °C

2: sodium azide / H₂O / 1 h / 0 °C

3: benzene / 3 h / Heating

4: 20percent HCl / 2 h / Heating

With hydrogenchloride; sodium azide; chloroformic acid ethyl ester; triethylamine; In water; acetone; benzene;

DOI:10.1248/cpb.35.3845

upstream raw materials:

diethyl tetrahydrothiophene-3,3-dicarboxylate

(-)-3-ethoxycarbonyltetrahydrothiophene-3-carboxylic acid

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