ethyl 2-(2-chloro-4-fluoro-3-methyl-5-nitrobenzoyl)-3-(dimethylamino)acrylate

Base Information

• Chemical Name: ethyl 2-(2-chloro-4-fluoro-3-methyl-5-nitrobenzoyl)-3-(dimethylamino)acrylate
• CAS No.: 173315-57-6
• Molecular Formula: C₁₅H₁₆ClFN₂O₅
• Molecular Weight: 358.754
• Mol file: 173315-57-6.mol

Synonyms:ethyl 2-(2-chloro-4-fluoro-3-methyl-5-nitrobenzoyl)-3-(dimethylamino)acrylate

Chemical Property of ethyl 2-(2-chloro-4-fluoro-3-methyl-5-nitrobenzoyl)-3-(dimethylamino)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-(2-chloro-4-fluoro-3-methyl-5-nitrobenzoyl)-3-(dimethylamino)acrylate

There total 3 articles about ethyl 2-(2-chloro-4-fluoro-3-methyl-5-nitrobenzoyl)-3-(dimethylamino)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-(dimethylamino)acrylate (924-99-2,1117-37-9,114894-59-6) + 2-chloro-4-fluoro-3-methyl-5-nitrobenzoyl chloride (173315-65-6) → ethyl 2-(2-chloro-4-fluoro-3-methyl-5-nitrobenzoyl)-3-(dimethylamino)acrylate (173315-57-6)

Guidance literature:

With triethylamine; In toluene; at 90 ℃; for 2h; Yield given;

DOI:10.1021/jm950558v

Reference yield:

2-chloro-6-fluorotoluene (443-83-4) → ethyl 2-(2-chloro-4-fluoro-3-methyl-5-nitrobenzoyl)-3-(dimethylamino)acrylate (173315-57-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) AlCl₃, 2.) Br₂, NaOH, 3.) 99.5percent HNO₃, 98percent H₂SO₄

2: SOCl₂ / 3 h / Heating

3: Et₃N / toluene / 2 h / 90 °C

With sodium hydroxide; aluminium trichloride; thionyl chloride; sulfuric acid; bromine; nitric acid; triethylamine; In toluene;

DOI:10.1021/jm950558v

Reference yield:

2-chloro-4-fluoro-3-methyl-5-nitrobenzoic acid (173315-56-5) → ethyl 2-(2-chloro-4-fluoro-3-methyl-5-nitrobenzoyl)-3-(dimethylamino)acrylate (173315-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 3 h / Heating

2: Et₃N / toluene / 2 h / 90 °C

With thionyl chloride; triethylamine; In toluene;

DOI:10.1021/jm950558v

upstream raw materials:

ethyl 3-(dimethylamino)acrylate

2-chloro-4-fluoro-3-methyl-5-nitrobenzoyl chloride

2-chloro-6-fluorotoluene

2-chloro-4-fluoro-3-methyl-5-nitrobenzoic acid

Downstream raw materials:

7-Fluoro-1-(4-fluoro-phenyl)-8-methyl-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

7-Fluoro-1-(4-methoxy-phenyl)-8-methyl-6-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

MF5137

6-Amino-1-(4-fluoro-phenyl)-8-methyl-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester