C-[4-(4-trifluoromethoxyphenyl)piperidin-4-yl]methylamine hydrochloride

Base Information

• Chemical Name: C-[4-(4-trifluoromethoxyphenyl)piperidin-4-yl]methylamine hydrochloride
• CAS No.: 1057384-04-9
• Molecular Formula: C₁₃H₁₇F₃N₂O*ClH
• Molecular Weight: 310.747
• Mol file: 1057384-04-9.mol

Synonyms:C-[4-(4-trifluoromethoxyphenyl)piperidin-4-yl]methylamine hydrochloride

Chemical Property of C-[4-(4-trifluoromethoxyphenyl)piperidin-4-yl]methylamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C-[4-(4-trifluoromethoxyphenyl)piperidin-4-yl]methylamine hydrochloride

There total 3 articles about C-[4-(4-trifluoromethoxyphenyl)piperidin-4-yl]methylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-aminomethyl-4-(4-trifluoromethoxyphenyl)piperidine-1-carboxylic acid tert-butyl ester (1057384-10-7) → C-[4-(4-trifluoromethoxyphenyl)piperidin-4-yl]methylamine hydrochloride (1057384-04-9)

Guidance literature:

With hydrogenchloride; methanol; water; at 20 ℃; for 18h;

Reference yield:

(4-trifluoromethoxy-phenyl)-acetonitrile (49561-96-8) → C-[4-(4-trifluoromethoxyphenyl)piperidin-4-yl]methylamine hydrochloride (1057384-04-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 20 - 60 °C

2: hydrogen / Raney nickel 2800 / ethanol / 20 h / 20 °C / 760.05 Torr

3: hydrogenchloride; methanol; water / 18 h / 20 °C

With hydrogenchloride; methanol; water; hydrogen; sodium hydride; Raney nickel 2800; In ethanol; N,N-dimethyl-formamide;

Reference yield:

tert-butyl 4-cyano-4-(4-(trifluoromethoxy)phenyl)piperidine-1-carboxylate (1057384-02-7) → C-[4-(4-trifluoromethoxyphenyl)piperidin-4-yl]methylamine hydrochloride (1057384-04-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / Raney nickel 2800 / ethanol / 20 h / 20 °C / 760.05 Torr

2: hydrogenchloride; methanol; water / 18 h / 20 °C

With hydrogenchloride; methanol; water; hydrogen; Raney nickel 2800; In ethanol;

upstream raw materials:

4-aminomethyl-4-(4-trifluoromethoxyphenyl)piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-cyano-4-(4-(trifluoromethoxy)phenyl)piperidine-1-carboxylate

(4-trifluoromethoxy-phenyl)-acetonitrile