(S)-6-((R)-4-benzyl-2-oxooxazolidin-3-yl)-5-(4-fluoro-3,5-dimethylbenzyl)-6-oxohexanal

Base Information

Chemical Name:(S)-6-((R)-4-benzyl-2-oxooxazolidin-3-yl)-5-(4-fluoro-3,5-dimethylbenzyl)-6-oxohexanal
CAS No.:1043453-88-8
Molecular Formula:C₂₅H₂₈FNO₄
Molecular Weight:425.5
Hs Code.:

Synonyms:(S)-6-((R)-4-benzyl-2-oxooxazolidin-3-yl)-5-(4-fluoro-3,5-dimethylbenzyl)-6-oxohexanal

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Chemical Property of (S)-6-((R)-4-benzyl-2-oxooxazolidin-3-yl)-5-(4-fluoro-3,5-dimethylbenzyl)-6-oxohexanal

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Technology Process of (S)-6-((R)-4-benzyl-2-oxooxazolidin-3-yl)-5-(4-fluoro-3,5-dimethylbenzyl)-6-oxohexanal

There total 7 articles about (S)-6-((R)-4-benzyl-2-oxooxazolidin-3-yl)-5-(4-fluoro-3,5-dimethylbenzyl)-6-oxohexanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (R)-4-benzyl-3-((S)-2-(4-fluoro-3,5-dimethylbenzyl)hept-6-enoyl)oxazolidin-2-one

: 1043453-88-8
(S)-6-((R)-4-benzyl-2-oxooxazolidin-3-yl)-5-(4-fluoro-3,5-dimethylbenzyl)-6-oxohexanal

Guidance literature:: With ozone; triphenylphosphine; In dichloromethane; at -78 - 25 ℃;

Reference yield: 83.0%

: 1043453-87-7
(R)-3-((S,E)-2-(4-fluoro-3,5-dimethylbenzyl)-8-methylnon-6-enoyl)-4-benzyloxazolidin-2-one

: 1043453-88-8
(S)-6-((R)-4-benzyl-2-oxooxazolidin-3-yl)-5-(4-fluoro-3,5-dimethylbenzyl)-6-oxohexanal

Guidance literature:: (R)-3-((S,E)-2-(4-fluoro-3,5-dimethylbenzyl)-8-methylnon-6-enoyl)-4-benzyloxazolidin-2-one; With ozone; In dichloromethane; at -78 ℃;

With oxygen; In dichloromethane; at -78 ℃;

With dimethylsulfide; In dichloromethane; at -78 - 20 ℃;

Reference yield:

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 1043453-88-8
(S)-6-((R)-4-benzyl-2-oxooxazolidin-3-yl)-5-(4-fluoro-3,5-dimethylbenzyl)-6-oxohexanal

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: -78 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

2.2: 3 h / -78 - 20 °C

3.1: ozone / dichloromethane / -78 °C

3.2: -78 °C

3.3: -78 - 20 °C

With n-butyllithium; ozone; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane;