benzyl 5-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)pentanoate

Base Information

Chemical Name:benzyl 5-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)pentanoate
CAS No.:943740-06-5
Molecular Formula:C₄₆H₅₁N₅O₉
Molecular Weight:817.939
Hs Code.:

Synonyms:benzyl 5-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)pentanoate

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Chemical Property of benzyl 5-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)pentanoate

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Technology Process of benzyl 5-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)pentanoate

There total 4 articles about benzyl 5-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 943740-05-4
2-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-(4-(5-(benzyloxy)-5-oxopentyl)phenyl)acetic acid

: 26177-43-5
3-nitrobenzylamine hydrochloride

: 943740-06-5
benzyl 5-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)pentanoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 943740-04-3
4-(5-(benzyloxy)-5-oxopentyl)phenylboronic acid

: 943740-06-5
benzyl 5-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 100 °C / Microwave irradiation

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide; dichloromethane / 20 °C

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b00788

Reference yield:

: 943740-03-2
(4-dihydroxyboryl-phenyl)pentanoic acid

: 943740-06-5
benzyl 5-(4-(2-(3-nitrobenzylamino)-1-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-oxoethyl)phenyl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2: 1,2-dichloro-ethane / 100 °C / Microwave irradiation

3: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide; dichloromethane / 20 °C

With 1-hydroxy-7-aza-benzotriazole; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b00788