(1,1-difluoro-3-(4'-(hexyloxy)biphenyl-4-yl)prop-2-ynyl)(p-tolyl)sulfane

Base Information

Chemical Name:(1,1-difluoro-3-(4'-(hexyloxy)biphenyl-4-yl)prop-2-ynyl)(p-tolyl)sulfane
CAS No.:1452822-57-9
Molecular Formula:C₂₈H₂₈F₂OS
Molecular Weight:450.593
Hs Code.:

Synonyms:(1,1-difluoro-3-(4'-(hexyloxy)biphenyl-4-yl)prop-2-ynyl)(p-tolyl)sulfane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1,1-difluoro-3-(4'-(hexyloxy)biphenyl-4-yl)prop-2-ynyl)(p-tolyl)sulfane

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Technology Process of (1,1-difluoro-3-(4'-(hexyloxy)biphenyl-4-yl)prop-2-ynyl)(p-tolyl)sulfane

There total 5 articles about (1,1-difluoro-3-(4'-(hexyloxy)biphenyl-4-yl)prop-2-ynyl)(p-tolyl)sulfane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1452822-33-1
(1,1,2,2-tetrafluoro-3-(4'-(hexyloxy)biphenyl-4-yl)propyl)(p-tolyl)sulfane

: 1452822-57-9
(1,1-difluoro-3-(4'-(hexyloxy)biphenyl-4-yl)prop-2-ynyl)(p-tolyl)sulfane

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -80 - 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201203315

Reference yield:

: 111-25-1
1-bromo-hexane

: 1452822-57-9
(1,1-difluoro-3-(4'-(hexyloxy)biphenyl-4-yl)prop-2-ynyl)(p-tolyl)sulfane

Guidance literature:: Multi-step reaction with 4 steps

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran / 2 h / -100 - -95 °C / Inert atmosphere

3.2: 2 h / -95 - -80 °C / Inert atmosphere

4.1: sodium hexamethyldisilazane / tetrahydrofuran / -80 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; sodium hexamethyldisilazane; potassium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 2.1: |Suzuki Coupling;
DOI:10.1002/chem.201203315

Reference yield:

: 842141-92-8
1-bromo-4-(3-bromo-2,2,3,3-tetrafluoropropyl)benzene

: 1452822-57-9
(1,1-difluoro-3-(4'-(hexyloxy)biphenyl-4-yl)prop-2-ynyl)(p-tolyl)sulfane

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / Reflux; Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran / 2 h / -100 - -95 °C / Inert atmosphere

2.2: 2 h / -95 - -80 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / -80 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butyl lithium; sodium hexamethyldisilazane; potassium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.1: |Suzuki Coupling;
DOI:10.1002/chem.201203315