(2-Oxo-1-phenyl-1,2-dihydro-quinolin-4-ylsulfanyl)-acetic acid

Base Information

• Chemical Name: (2-Oxo-1-phenyl-1,2-dihydro-quinolin-4-ylsulfanyl)-acetic acid
• CAS No.: 166191-74-8
• Molecular Formula: C₁₇H₁₃NO₃S
• Molecular Weight: 311.361
• Mol file: 166191-74-8.mol

Synonyms:(2-Oxo-1-phenyl-1,2-dihydro-quinolin-4-ylsulfanyl)-acetic acid

Chemical Property of (2-Oxo-1-phenyl-1,2-dihydro-quinolin-4-ylsulfanyl)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (2-Oxo-1-phenyl-1,2-dihydro-quinolin-4-ylsulfanyl)-acetic acid

There total 2 articles about (2-Oxo-1-phenyl-1,2-dihydro-quinolin-4-ylsulfanyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

mercaptoacetic acid (68-11-1) + 4-chloro-1-phenyl-2(1H)-quinolone (110254-63-2) → (2-Oxo-1-phenyl-1,2-dihydro-quinolin-4-ylsulfanyl)-acetic acid (166191-74-8)

Guidance literature:

With potassium carbonate; triethylamine; In methanol; for 8h; Heating;

Reference yield:

4-hydroxy-1-phenylquinolin-2(1H)-one (14994-75-3) → (2-Oxo-1-phenyl-1,2-dihydro-quinolin-4-ylsulfanyl)-acetic acid (166191-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₃, POCl₃ / 5 h / Heating

2: 95 percent / K₂CO₃, Et₃N / methanol / 8 h / Heating

With potassium carbonate; triethylamine; trichlorophosphate; phosphorus trichloride; In methanol;

Reference yield: 62.0%

(2-Oxo-1-phenyl-1,2-dihydro-quinolin-4-ylsulfanyl)-acetic acid (166191-74-8) → 3-Hydroxy-5-phenyl-5H-thieno[3,2-c]quinolin-4-one (166191-80-6)

Guidance literature:

With PPA; at 175 - 180 ℃; for 3h;

upstream raw materials:

mercaptoacetic acid

4-chloro-1-phenyl-2(1H)-quinolone

4-hydroxy-1-phenylquinolin-2(1H)-one

Downstream raw materials:

3-Hydroxy-5-phenyl-5H-thieno[3,2-c]quinolin-4-one