6-(Chloromethyl)quinoline

Base Information

• Chemical Name: 6-(Chloromethyl)quinoline
• CAS No.: 2644-82-8
• Molecular Formula: C10H8ClN
• Molecular Weight: 177.633
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID10562780
• Nikkaji Number: J345.907A
• Wikidata: Q72455147
• Mol file: 2644-82-8.mol

Synonyms:6-(chloromethyl)quinoline;2644-82-8;6-CHLOROMETHYLQUINOLINE;MFCD09040306;Quinoline, 6-(chloromethyl)-;6-chloromethyl-quinoline;SCHEMBL1496327;DTXSID10562780;OBNGWZDUQKEARE-UHFFFAOYSA-N;AKOS000795946;SB67678;MS-20658;EN300-111994;A818448;2-AMINOMETHYL-3-(2-TRIFLUOROMETHOXY-PHENYL)-PROPIONICACID

Chemical Property of 6-(Chloromethyl)quinoline

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 69-71 °C
• Refractive Index: 1.638
• Boiling Point: 310.579 °C at 760 mmHg
• Flash Point: 170.617 °C
• PSA: 12.89000
• Density: 1.23 g/cm³
• LogP: 2.97360
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 177.0345270
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

97% ^*data from raw suppliers

6-(Chloromethyl)quinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CC(=C2)CCl)N=C1

Technology Process of 6-(Chloromethyl)quinoline

There total 3 articles about 6-(Chloromethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

6-(hydroxymethyl)quinoline (100516-88-9) → 6-(chloromethyl)quinoline (2644-82-8)

Guidance literature:

With thionyl chloride; In acetonitrile;

Reference yield:

[6]quinolyl-methanol; hydrochloride → 6-(chloromethyl)quinoline (2644-82-8)

Guidance literature:

With thionyl chloride; benzene;

DOI:10.1021/ja01609a087

Reference yield:

→ 6-(chloromethyl)quinoline (2644-82-8)

Guidance literature:

Chinolyl-(6)-carbinol , HCl (...?) durch 4-stdg. Δ auf 130-140grad ( modifizierte Synth. );

upstream raw materials:

6-(hydroxymethyl)quinoline

Downstream raw materials:

2-(quinolin-6-yl)acetonitrile

N,N-bis-[6]quinolylmethyl-aniline

quinolin-6-ylmethanamine

6-iodomethyl-quinoline