(R)-1-((5E,8E)-5,8-bis(hydroxyimino)-1,4-dimethoxy-5,8-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 4-methoxybenzoate

Base Information

• Chemical Name: (R)-1-((5E,8E)-5,8-bis(hydroxyimino)-1,4-dimethoxy-5,8-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 4-methoxybenzoate
• CAS No.: 1622443-55-3
• Molecular Formula: C₂₆H₂₈N₂O₇
• Molecular Weight: 480.518
• Mol file: 1622443-55-3.mol

Synonyms:(R)-1-((5E,8E)-5,8-bis(hydroxyimino)-1,4-dimethoxy-5,8-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 4-methoxybenzoate

Chemical Property of (R)-1-((5E,8E)-5,8-bis(hydroxyimino)-1,4-dimethoxy-5,8-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 4-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-((5E,8E)-5,8-bis(hydroxyimino)-1,4-dimethoxy-5,8-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 4-methoxybenzoate

There total 5 articles about (R)-1-((5E,8E)-5,8-bis(hydroxyimino)-1,4-dimethoxy-5,8-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 4-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ (R)-1-((5E,8E)-5,8-bis(hydroxyimino)-1,4-dimethoxy-5,8-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 4-methoxybenzoate (1622443-55-3)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol;

Reference yield:

1-(1,4-dihydro-5,8-dimethoxy-1,4-dioxonaphthalen-6-yl)-4-methylpent-3-enyl 4-methoxybenzoate (1314765-84-8) → (R)-1-((5E,8E)-5,8-bis(hydroxyimino)-1,4-dimethoxy-5,8-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 4-methoxybenzoate (1622443-55-3)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol;

DOI:10.1016/j.bmcl.2014.07.012

Reference yield:

4-methoxybenzoic acid (100-09-4) → (R)-1-((5E,8E)-5,8-bis(hydroxyimino)-1,4-dimethoxy-5,8-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 4-methoxybenzoate (1622443-55-3)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere

2: ammonium cerium (IV) nitrate / water / 0.25 h / 0 °C

3: hydroxylamine hydrochloride; pyridine / ethanol

With pyridine; dmap; ammonium cerium (IV) nitrate; hydroxylamine hydrochloride; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2014.07.012

upstream raw materials:

4-methoxybenzoic acid

(1R)-4-methyl-1-(1,4,5,8-tetramethoxynaphthalen-2-yl)pent-3-en-1-ol

1-(1,4-dihydro-5,8-dimethoxy-1,4-dioxonaphthalen-6-yl)-4-methylpent-3-enyl 4-methoxybenzoate

C₂₈H₃₂O₇