(R)-(+)-ethyl 4-hydroxy-4-phenylbutanoate

Base Information

Chemical Name:(R)-(+)-ethyl 4-hydroxy-4-phenylbutanoate
CAS No.:158252-36-9
Molecular Formula:C₁₂H₁₆O₃
Molecular Weight:208.257
Hs Code.:

Synonyms:(R)-(+)-ethyl 4-hydroxy-4-phenylbutanoate

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Chemical Property of (R)-(+)-ethyl 4-hydroxy-4-phenylbutanoate

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Technology Process of (R)-(+)-ethyl 4-hydroxy-4-phenylbutanoate

There total 2 articles about (R)-(+)-ethyl 4-hydroxy-4-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 6270-17-3
ethyl 3-benzoylpropanoate

: 158252-36-9
(R)-(+)-ethyl 4-hydroxy-4-phenylbutanoate

Guidance literature:: With C₂₂H₂₇Cl₂CoN₃O; sodium triethylborohydride; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 20 ℃; for 24h; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c5cc01084e

Reference yield:

: 6270-17-3
ethyl 3-benzoylpropanoate

: 158252-36-9
(R)-(+)-ethyl 4-hydroxy-4-phenylbutanoate

: (S)-ethyl 4-hydroxy-4-phenylbutanoate

Guidance literature:: With Trichosporon cutaneum CGMCC 2.1795; In ethanol; at 30 ℃; for 24h; pH=6.8; Reagent/catalyst; Overall yield = 51 %; enantioselective reaction; Enzymatic reaction;
DOI:10.3109/10242422.2012.758116

Reference yield: 43.0%

: 158252-36-9
(R)-(+)-ethyl 4-hydroxy-4-phenylbutanoate

: 74425-65-3
6-hydroxy-6-methyl-2H-pyran-3(6H)-one

: (2R)-ethyl 2-(2-methyl-5-oxo-5,6-dihydro-2H-pyran-2-yloxy)-4-phenylbutanoate

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at -78 ℃; for 1h; optical yield given as %ee; Inert atmosphere; Molecular sieve;
DOI:10.1021/ol901523g