(R)-3-AMINO-3-(3-METHOXY-PHENYL)-PROPIONIC ACID

Base Information

• Chemical Name: (R)-3-AMINO-3-(3-METHOXY-PHENYL)-PROPIONIC ACID
• CAS No.: 765895-65-6
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• Mol file: 765895-65-6.mol

Synonyms:(R)-3-Amino-3-(3-methoxyphenyl)propanoic acid;

Chemical Property of (R)-3-AMINO-3-(3-METHOXY-PHENYL)-PROPIONIC ACID

Chemical Property:

• Melting Point: 215-216 °C
• Boiling Point: 350.2 °C at 760 mmHg
• PKA: 3.68±0.10(Predicted)
• Flash Point: 165.6 °C
• PSA: 72.55000
• Density: 1.206 g/cm³
• LogP: 1.87000
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

(R)-3-Amino-3-(3-methoxyphenyl)propanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-AMINO-3-(3-METHOXY-PHENYL)-PROPIONIC ACID

There total 18 articles about (R)-3-AMINO-3-(3-METHOXY-PHENYL)-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl (R)-3-amino-3-(3-methoxyphenyl)propanoate (951174-38-2) → (R)-3-amino-3-(3-methoxyphenyl)propanoic acid (783300-35-6,765895-65-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1016/j.tetasy.2007.06.008

Reference yield: 65.0%

malonic acid (141-82-2) + 3-methoxy-benzaldehyde (591-31-1) → 3-amino-3-(3-methoxy-phenyl)-propionic acid (68208-19-5,783300-35-6,765895-65-6)

Guidance literature:

With ammonium acetate; In ethanol; at 87 ℃; for 16h;

DOI:10.1039/d1ob01306h

Reference yield:

malonic acid (141-82-2) + 3-methoxy-benzaldehyde (591-31-1) → 3-methoxycinnamic acid (6099-04-3,17570-26-2) + 3-amino-3-(3-methoxy-phenyl)-propionic acid (68208-19-5,783300-35-6,765895-65-6)

Guidance literature:

With ammonia;

upstream raw materials:

3-methoxycinnamic acid

3-methoxy-cinnamic acid methyl ester

malonic acid

3-methoxy-benzaldehyde

Refernces

• 1、 MacDonald, Simon J. F.,Nortcliffe, Andrew,Robinson, Henry,Simelis, Klemensas,Stillibrand, Joe. "Iridium-catalysed C-H borylation of β-aryl-aminopropionic acids". supporting information. p. 6696 - 6701. Retrieved 2020/09/21.
• 2、 Weise, Nicholas J.,Parmeggiani, Fabio,Ahmed, Syed T.,Turner, Nicholas J.. "The bacterial ammonia lyase EncP: A tunable biocatalyst for the synthesis of unnatural amino acids". supporting information. p. 12977 - 12983. Retrieved 2015/10/28.