(2R)-2-methyl-3-[2H₃]methyl-3-(phenylsulfonyl)-[4-2H₃]butyl 4-methylbenzenesulfonate

Base Information

• Chemical Name: (2R)-2-methyl-3-[2H₃]methyl-3-(phenylsulfonyl)-[4-2H₃]butyl 4-methylbenzenesulfonate
• CAS No.: 497924-45-5
• Molecular Formula: C₁₉H₂₄O₅S₂
• Molecular Weight: 402.481

Synonyms:(2R)-2-methyl-3-[2H₃]methyl-3-(phenylsulfonyl)-[4-2H₃]butyl 4-methylbenzenesulfonate

Chemical Property of (2R)-2-methyl-3-[2H₃]methyl-3-(phenylsulfonyl)-[4-2H₃]butyl 4-methylbenzenesulfonate

Chemical Property:

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Technology Process of (2R)-2-methyl-3-[2H₃]methyl-3-(phenylsulfonyl)-[4-2H₃]butyl 4-methylbenzenesulfonate

There total 2 articles about (2R)-2-methyl-3-[2H₃]methyl-3-(phenylsulfonyl)-[4-2H₃]butyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

p-toluenesulfonyl chloride (98-59-9) + (2R)-2-methyl-3-[2H3]methyl-3-(phenylsulfonyl)-[4-2H3]butan-1-ol (497924-44-4) → (2R)-2-methyl-3-[2H3]methyl-3-(phenylsulfonyl)-[4-2H3]butyl 4-methylbenzenesulfonate (497924-45-5)

Guidance literature:

With pyridine; at 20 ℃; for 3h;

DOI:10.1016/S0039-128X(02)00071-5

Reference yield:

2-[(2R)-2-methyl-3-[2H3]methyl-3-phenylsulfonyl-[4-(2)H3]butyloxy]tetrahydro-2H-pyran (497924-43-3) → (2R)-2-methyl-3-[2H3]methyl-3-(phenylsulfonyl)-[4-2H3]butyl 4-methylbenzenesulfonate (497924-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / conc. HCl / methanol / 0.67 h / 20 °C

2: 92 percent / pyridine / 3 h / 20 °C

With pyridine; hydrogenchloride; In methanol;

DOI:10.1016/S0039-128X(02)00071-5

Reference yield: 68.0%

thiophenol (108-98-5) + (2R)-2-methyl-3-[2H3]methyl-3-(phenylsulfonyl)-[4-2H3]butyl 4-methylbenzenesulfonate (497924-45-5) → (2R)-2-methyl-3-[2H3]methyl-1-(phenylsulfanyl)-3-(phenylsulfonyl)[4-2H3]butane (497924-46-6)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 40h;

DOI:10.1016/S0039-128X(02)00071-5

upstream raw materials:

p-toluenesulfonyl chloride

(2R)-2-methyl-3-[2H₃]methyl-3-(phenylsulfonyl)-[4-2H₃]butan-1-ol

2-[(2R)-2-methyl-3-[2H₃]methyl-3-phenylsulfonyl-[4-⁽²⁾H₃]butyloxy]tetrahydro-2H-pyran

Downstream raw materials:

(2R)-2-methyl-3-[2H₃]methyl-1-(phenylsulfanyl)-3-(phenylsulfonyl)[4-2H₃]butane

(2S)-2-methyl-3-[2H₃]methyl[4-2H₃]butyl phenyl sulfide

(2S)-2-methyl-3-[2H₃]methyl[4-2H₃]butyl phenyl sulfone

C₃₆H₄₆⁽²⁾H₆O₅S

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