C₂₁H₃₆O₈

Base Information

Chemical Name:C₂₁H₃₆O₈
CAS No.:1313484-38-6
Molecular Formula:C₂₁H₃₆O₈
Molecular Weight:416.512
Hs Code.:

C<sub>21</sub>H<sub>36</sub>O<sub>8</sub>

Synonyms:C₂₁H₃₆O₈

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Chemical Property of C₂₁H₃₆O₈

Chemical Property:

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Technology Process of C₂₁H₃₆O₈

There total 24 articles about C₂₁H₃₆O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313484-37-5
C₂₁H₃₆O₈

: 1313484-38-6
C₂₁H₃₆O₈

: C₂₁H₃₆O₈

Guidance literature:: C₂₁H₃₆O₈; With potassium hexamethylsilazane; In toluene; at -78 ℃; for 2h; Inert atmosphere;

With chloro-trimethyl-silane; In toluene; at -78 - 85 ℃; for 20.5h; optical yield given as %de; Inert atmosphere;
DOI:10.1039/c1cc11388g

Reference yield:

: 928618-22-8
(2'S,3'S,4R,5R)-2-hydroxymethyl-4-O,5-O-(2',3'-dimethoxybutane-2',3'-diyl)-4,5-dihydroxycyclohex-2-en-1-one

: 1313484-38-6
C₂₁H₃₆O₈

: C₂₁H₃₆O₈

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap; triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

2.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 0 °C / Inert atmosphere

3.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.25 h / 0 °C / Inert atmosphere

4.1: triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid / toluene / 15 h / 20 °C / Inert atmosphere

4.2: 2 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane; water / 0.17 h / 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine; sodium iodide / tetrahydrofuran / 4.5 h / 20 °C / Reflux; Inert atmosphere

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

8.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 19 h / 20 °C / Inert atmosphere

9.1: potassium hexamethylsilazane / toluene / 2 h / -78 °C / Inert atmosphere

9.2: 20.5 h / -78 - 85 °C / Inert atmosphere

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; cerium(III) chloride heptahydrate; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium iodide; lithium hexamethyldisilazane; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 3.1: Luche reduction / 4.2: Mitsunobu reaction / 9.1: Ireland-Claisen rearrangement / 9.2: Ireland-Claisen rearrangement;
DOI:10.1039/c1cc11388g

Reference yield:

: 77-95-2
D-(-)-quinic acid

: 1313484-38-6
C₂₁H₃₆O₈

: C₂₁H₃₆O₈

Guidance literature:: Multi-step reaction with 14 steps

1.1: camphorsulfonic acid / methanol / 16 h / Reflux; Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

3.1: silica gel-supported NaIO₄ / methanol; dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4.2: 3.5 h / 0 - 20 °C / Inert atmosphere

5.1: 1H-imidazole; sodium hydrogencarbonate / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

6.1: dmap; triethylamine / dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

7.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

7.2: 1 h / -78 - 0 °C / Inert atmosphere

8.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.25 h / 0 °C / Inert atmosphere

9.1: triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid / toluene / 15 h / 20 °C / Inert atmosphere

9.2: 2 h / 20 °C / Inert atmosphere

10.1: trifluoroacetic acid / dichloromethane; water / 0.17 h / 20 °C / Inert atmosphere

11.1: N-ethyl-N,N-diisopropylamine; sodium iodide / tetrahydrofuran / 4.5 h / 20 °C / Reflux; Inert atmosphere

12.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

13.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 19 h / 20 °C / Inert atmosphere

14.1: potassium hexamethylsilazane / toluene / 2 h / -78 °C / Inert atmosphere

14.2: 20.5 h / -78 - 85 °C / Inert atmosphere

With 1H-imidazole; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; cerium(III) chloride heptahydrate; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium iodide; lithium hexamethyldisilazane; diethylazodicarboxylate; 4-nitro-benzoic acid; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 5.1: Baylis-Hillman reaction / 8.1: Luche reduction / 9.2: Mitsunobu reaction / 14.1: Ireland-Claisen rearrangement / 14.2: Ireland-Claisen rearrangement;
DOI:10.1039/c1cc11388g