2-amino-7'-(3-chloro-5-fluorophenyl)-1-methyl-1',4',4a',9a'-tetrahydrospiro[imidazole-4,9'-xanthene]-3',5(1H,2'H)-dione

Base Information

Chemical Name:2-amino-7'-(3-chloro-5-fluorophenyl)-1-methyl-1',4',4a',9a'-tetrahydrospiro[imidazole-4,9'-xanthene]-3',5(1H,2'H)-dione
CAS No.:1369626-40-3
Molecular Formula:C₂₂H₁₉ClFN₃O₃
Molecular Weight:427.863
Hs Code.:

Synonyms:2-amino-7'-(3-chloro-5-fluorophenyl)-1-methyl-1',4',4a',9a'-tetrahydrospiro[imidazole-4,9'-xanthene]-3',5(1H,2'H)-dione

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Chemical Property of 2-amino-7'-(3-chloro-5-fluorophenyl)-1-methyl-1',4',4a',9a'-tetrahydrospiro[imidazole-4,9'-xanthene]-3',5(1H,2'H)-dione

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Technology Process of 2-amino-7'-(3-chloro-5-fluorophenyl)-1-methyl-1',4',4a',9a'-tetrahydrospiro[imidazole-4,9'-xanthene]-3',5(1H,2'H)-dione

There total 10 articles about 2-amino-7'-(3-chloro-5-fluorophenyl)-1-methyl-1',4',4a',9a'-tetrahydrospiro[imidazole-4,9'-xanthene]-3',5(1H,2'H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369627-78-0
2-amino-7'-bromo-1-methyl-1',4',4a',9a'-tetrahydrospiro[imidazole-4,9'-xanthene]-3',5(1H,2'H)-dione

: 328956-61-2
3-fluoro-5-chlorophenylboronic acid

: 1369626-40-3
2-amino-7'-(3-chloro-5-fluorophenyl)-1-methyl-1',4',4a',9a'-tetrahydrospiro[imidazole-4,9'-xanthene]-3',5(1H,2'H)-dione

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 90 ℃; Inert atmosphere; Capped vial;

Reference yield:

: 52817-12-6
6-bromo-4-oxo-4H-chromene-3-carbaldehyde

: 1369626-40-3
2-amino-7'-(3-chloro-5-fluorophenyl)-1-methyl-1',4',4a',9a'-tetrahydrospiro[imidazole-4,9'-xanthene]-3',5(1H,2'H)-dione

Guidance literature:: Multi-step reaction with 10 steps

1.1: zinc(II) iodide / dichloromethane / 1.5 h / 0 °C

1.2: 0.25 h / 20 °C / Molecular sieve

2.1: hydrogenchloride / ethanol / 18 h / 100 °C

3.1: toluene-4-sulfonic acid / toluene / 4 h / 130 - 135 °C / Dean-Stark apparatus

4.1: sodium hydrogensulfite; ammonium carbonate / ethanol / 18 h / 135 °C / Sealed reactor

5.1: potassium hydroxide; water / 195 °C

5.2: pH 7 / Cooling

6.1: hexanes; methanol

7.1: triethylamine / N,N-dimethyl-formamide / 24 h / 65 °C

8.1: tert.-butylhydroperoxide; ammonia / water; methanol / 24 h / 20 °C

9.1: hydrogenchloride; water / acetone / 24 h / 65 °C

10.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 90 °C / Inert atmosphere; Capped vial

With hydrogenchloride; tert.-butylhydroperoxide; ammonia; water; ammonium carbonate; sodium carbonate; sodium hydrogensulfite; triethylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; toluene-4-sulfonic acid; zinc(II) iodide; In 1,4-dioxane; methanol; hexanes; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 7'-bromo-1',4',4a',9a'-tetrahydrospiro[[1,3]dioxolane-2,3'-xanthene]-9'(2'H)-one

: 1369626-40-3
2-amino-7'-(3-chloro-5-fluorophenyl)-1-methyl-1',4',4a',9a'-tetrahydrospiro[imidazole-4,9'-xanthene]-3',5(1H,2'H)-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogensulfite; ammonium carbonate / ethanol / 18 h / 135 °C / Sealed reactor

2.1: potassium hydroxide; water / 195 °C

2.2: pH 7 / Cooling

3.1: hexanes; methanol

4.1: triethylamine / N,N-dimethyl-formamide / 24 h / 65 °C

5.1: tert.-butylhydroperoxide; ammonia / water; methanol / 24 h / 20 °C

6.1: hydrogenchloride; water / acetone / 24 h / 65 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 90 °C / Inert atmosphere; Capped vial

With hydrogenchloride; tert.-butylhydroperoxide; ammonia; water; ammonium carbonate; sodium carbonate; sodium hydrogensulfite; triethylamine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; hexanes; ethanol; water; N,N-dimethyl-formamide; acetone;