2-(3,4-Dihydro-2H-quinolin-1-YL)-ethylamine

Base Information

• Chemical Name: 2-(3,4-Dihydro-2H-quinolin-1-YL)-ethylamine
• CAS No.: 37481-18-8
• Molecular Formula: C₁₁H₁₆N₂
• Molecular Weight: 176.261
• Hs Code.: 2933499090
• European Community (EC) Number: 837-763-1
• ChEMBL ID: CHEMBL4073689
• DSSTox Substance ID: DTXSID50588424
• Nikkaji Number: J2.466.365E
• Wikidata: Q72436991
• Mol file: 37481-18-8.mol

Synonyms:37481-18-8;2-(3,4-DIHYDRO-2H-QUINOLIN-1-YL)-ETHYLAMINE;2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine;2-(3,4-dihydro-2H-quinolin-1-yl)ethanamine;2-(1,2,3,4-TETRAHYDROQUINOLIN-1-YL)ETHAN-1-AMINE;2-(3,4-Dihydro-2h-quinolin-1-yl)ethylamine;MFCD06738984;2-[3,4-Dihydroquinolin-1(2H)-yl]ethylamine;2-(3,4-dihydroquinolin-1(2H)-yl)ethan-1-amine;SCHEMBL4700805;CHEMBL4073689;DTXSID50588424;AKOS000138725;AB28315;MCULE-2173966328;BS-25119;SY040444;CS-0005454;EN300-58184;S10657;A823694;F2187-2208;N-(2-Aminoethyl)-1 pound not2 pound not3 pound not4-tetrahydroquinoline

Chemical Property of 2-(3,4-Dihydro-2H-quinolin-1-YL)-ethylamine

Chemical Property:

• Refractive Index: 1.564
• Boiling Point: 318.8 °C at 760 mmHg
• PKA: 8.80±0.10(Predicted)
• Flash Point: 128.4 °C
• PSA: 29.26000
• Density: 1.045 g/cm³
• LogP: 2.16320
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 176.131348519
• Heavy Atom Count: 13
• Complexity: 158

Purity/Quality:

97% ^*data from raw suppliers

2-(3,4-Dihydro-2H-quinolin-1-yl)-ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=CC=CC=C2N(C1)CCN

Technology Process of 2-(3,4-Dihydro-2H-quinolin-1-YL)-ethylamine

There total 6 articles about 2-(3,4-Dihydro-2H-quinolin-1-YL)-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1,2,3,4-tetrahydroisoquinoline (635-46-1) + 2-bromoethylamine hydrobromide (2576-47-8) → N-(β-aminoethyl)tetrahydroquinoline (37481-18-8)

Guidance literature:

1,2,3,4-tetrahydroisoquinoline; 2-bromoethylamine hydrobromide; With sodium hydrogencarbonate; In water; at 95 ℃; for 3.75h; Reflux;

With sodium hydroxide; In water; at 20 ℃;

DOI:10.1007/s11172-016-1570-1

Reference yield:

N-(2-(3,4-dihydroquinolin-1(2H)-yl)ethyl)formamide → N-(β-aminoethyl)tetrahydroquinoline (37481-18-8)

Guidance literature:

With hydrogenchloride; In methanol; at 75 ℃; for 1.5h;

DOI:10.1016/j.bmcl.2019.126929

Reference yield:

2-(3,4-dihydroquinolin-1(2H)-yl)acetonitrile (66487-31-8) → N-(β-aminoethyl)tetrahydroquinoline (37481-18-8)

Guidance literature:

2-(3,4-dihydroquinolin-1(2H)-yl)acetonitrile; With lithium aluminium tetrahydride; aluminum (III) chloride; In diethyl ether; for 0.5h;

With sodium hydroxide; water; In diethyl ether;

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline

chloroethylamine

2-(3,4-dihydroquinolin-1(2H)-yl)acetonitrile

2-bromoethylamine hydrobromide

Downstream raw materials:

perfluorophenyl 4-(4-(4-(5-(2-(3,4-dihydroquinolin-1(2H)-yl)ethylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl)benzoyl)benzamido)-1-methyl-1H-pyrrole-2-carboxylate