6,7-dimethoxy-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:6,7-dimethoxy-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline
CAS No.:121580-34-5
Molecular Formula:C₁₃H₁₄F₃NO₃
Molecular Weight:289.254
Hs Code.:
Mol file:121580-34-5.mol

Synonyms:2,2,2-trifluoro-1-(1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolin-2(1H)-yl)ethanone

Suppliers and Price of 6,7-dimethoxy-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 6,7-dimethoxy-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6,7-dimethoxy-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about 6,7-dimethoxy-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1745-07-9
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 407-25-0
trifluoroacetic anhydride

: 121580-34-5
2,2,2-trifluoro-1-(1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolin-2(1H)-yl)ethanone

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ja0619455

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 121580-34-5
2,2,2-trifluoro-1-(1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolin-2(1H)-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid / 11 h / 50 °C

2: 90 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; formic acid; In dichloromethane;
DOI:10.1021/ja0619455

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 121580-34-5
2,2,2-trifluoro-1-(1,2,3,4-tetrahydro-6,7-dimethoxyisoquinolin-2(1H)-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: Na₂SO₄ / 1,2-dichloro-ethane / 0.5 h / Heating

2: 1.) SOCl₂, KI / 1.) 1,2-dichloroethane, room temp., 1 h, 2.) room temp., 3 h

With thionyl chloride; sodium sulfate; potassium iodide; In 1,2-dichloro-ethane;
DOI:10.1055/s-1989-27153