3-AMINO-5,5-DIMETHYL-HEXANOIC ACID

Base Information

• Chemical Name: 3-AMINO-5,5-DIMETHYL-HEXANOIC ACID
• CAS No.: 727971-57-5
• Molecular Formula: C₈H₁₇NO₂
• Molecular Weight: 159.228
• Mol file: 727971-57-5.mol

Synonyms:RARECHEM AL BK 0708;3-AMINO-5,5-DIMETHYL-HEXANOIC ACID

Chemical Property of 3-AMINO-5,5-DIMETHYL-HEXANOIC ACID

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Boiling Point: 259.189°C at 760 mmHg
• Flash Point: 110.554°C
• PSA: 63.32000
• Density: 0.999g/cm³
• LogP: 1.92490

Purity/Quality:

98% ^*data from raw suppliers

3-Amino-5,5-dimethylhexanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-5,5-DIMETHYL-HEXANOIC ACID

There total 5 articles about 3-AMINO-5,5-DIMETHYL-HEXANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H25NO4 (1370687-52-7) → C8H17NO2 (218608-81-2,727971-57-5)

Guidance literature:

With tert-butyl alcohol; In water; at 60 ℃; for 36h;

DOI:10.1021/op300069n

Reference yield:

(3R)-ethyl 5,5-dimethyl-3-(tosylamino)hexanoate (147228-25-9) → (3R)-3-amino-5,5-dimethylhexanoic acid (147228-35-1,218608-81-2,727971-57-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / K₂CO₃ / methanol; H₂O / 24 h / Ambient temperature

2: 1.) 47percent aq. HBr, 2.) methyloxirane / 1.) phenol, reflux, 4 h, 2.) EtOH, reflux, 2 h

With hydrogen bromide; potassium carbonate; methyloxirane; In methanol; water;

DOI:10.1002/hlca.19960790426

Reference yield:

C27H43NO9 (1370639-71-6) → C8H17NO2 (218608-81-2,727971-57-5)

Guidance literature:

Multi-step reaction with 2 steps

1: perchloric acid / water; acetonitrile / 23 °C

2: tert-butyl alcohol / water / 36 h / 60 °C

With perchloric acid; tert-butyl alcohol; In water; acetonitrile;

DOI:10.1021/op300069n

upstream raw materials:

(3R)-5,5-dimethyl-3-(tosylamino)hexanoic acid

(3R)-ethyl 5,5-dimethyl-3-(tosylamino)hexanoate

C₂₇H₄₃NO₉

C₁₅H₂₅NO₄

Refernces

• 1、 Jefford, Charles W.,McNulty, James,Lu, Zhi-Hui,Wang, Jian Bo. "104. The enantioselective synthesis of β-amino acids, their α-hydroxy derivatives, and the N-terminal components of bestatin and microginin". . p. 1203 - 1216. Retrieved 2007/10/03.