2-(((3',4'-dimethoxyphenyl)methoxy)methyl)-6-((5'-imidazolyl)methyl)toluene

Base Information

Chemical Name:2-(((3',4'-dimethoxyphenyl)methoxy)methyl)-6-((5'-imidazolyl)methyl)toluene
CAS No.:154148-86-4
Molecular Formula:C₂₁H₂₄N₂O₃
Molecular Weight:352.433
Hs Code.:

Synonyms:2-(((3',4'-dimethoxyphenyl)methoxy)methyl)-6-((5'-imidazolyl)methyl)toluene

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Chemical Property of 2-(((3',4'-dimethoxyphenyl)methoxy)methyl)-6-((5'-imidazolyl)methyl)toluene

Chemical Property:

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Technology Process of 2-(((3',4'-dimethoxyphenyl)methoxy)methyl)-6-((5'-imidazolyl)methyl)toluene

There total 4 articles about 2-(((3',4'-dimethoxyphenyl)methoxy)methyl)-6-((5'-imidazolyl)methyl)toluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 154148-85-3
2-(((3',4'-dimethoxyphenyl)methoxy)methyl)-6-(1'-hydroxy-1'-(5''-imidazolyl)methyl)toluene

: 154148-86-4
2-(((3',4'-dimethoxyphenyl)methoxy)methyl)-6-((5'-imidazolyl)methyl)toluene

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; at 25 - 60 ℃; for 6h; under 3102.9 Torr;
DOI:10.1002/jhet.5570300631

Reference yield:

: 83647-43-2
3-bromo-2-methylbenzyl alcohol

: 154148-86-4
2-(((3',4'-dimethoxyphenyl)methoxy)methyl)-6-((5'-imidazolyl)methyl)toluene

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / 1.) NaH / dimethylformamide / 1.) 0 deg.C, 30 min, 2.) 30 deg.C, 3 h

2: 1.) Mg / 1.) THF, reflux, 2.5 h, 2.) THF, reflux 3 h

3: 22 percent / H₂, CH₃COOH / 10percent Pd/C / 6 h / 25 - 60 °C / 3102.9 Torr

With hydrogen; sodium hydride; magnesium; acetic acid; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570300631

Reference yield:

: 529-20-4
2-methylphenyl aldehyde

: 154148-86-4
2-(((3',4'-dimethoxyphenyl)methoxy)methyl)-6-((5'-imidazolyl)methyl)toluene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) AlCl₃, Br₂, 2.) NaBH₄ / 1.) CH₂Cl₂, 40 deg.C, 30 min, 2.) CH₃OH, 0 deg.C, 2 h

2: 75 percent / 1.) NaH / dimethylformamide / 1.) 0 deg.C, 30 min, 2.) 30 deg.C, 3 h

3: 1.) Mg / 1.) THF, reflux, 2.5 h, 2.) THF, reflux 3 h

4: 22 percent / H₂, CH₃COOH / 10percent Pd/C / 6 h / 25 - 60 °C / 3102.9 Torr

With sodium tetrahydroborate; aluminium trichloride; hydrogen; bromine; sodium hydride; magnesium; acetic acid; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570300631