3-Amino-3-(3,4-dimethoxyphenyl)propionic acid

Base Information

• Chemical Name: 3-Amino-3-(3,4-dimethoxyphenyl)propionic acid
• CAS No.: 34841-09-3
• Molecular Formula: C₁₁H₁₅NO₄
• Molecular Weight: 225.244
• Hs Code.: 29224999
• Mol file: 34841-09-3.mol

Synonyms:Hydrocinnamicacid, b-amino-3,4-dimethoxy- (6CI);3-Amino-3-(3,4-dimethoxyphenyl)propionic acid;b-Amino-3,4-dimethoxyhydrocinnamic acid;

Chemical Property of 3-Amino-3-(3,4-dimethoxyphenyl)propionic acid

Chemical Property:

• Vapor Pressure: 1.93E-06mmHg at 25°C
• Melting Point: 223 °C (dec.)(lit.)
• Refractive Index: 1.546
• Boiling Point: 379.7 °C at 760 mmHg
• PKA: 3.73±0.10(Predicted)
• Flash Point: 183.4 °C
• PSA: 81.78000
• Density: 1.212g/cm³
• LogP: 1.87860
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-3-(3,4-dimethoxyphenyl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-3-(3,4-dimethoxyphenyl)propionic acid

There total 7 articles about 3-Amino-3-(3,4-dimethoxyphenyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

→ 3-amino-3-(3,4-dimethoxyphenyl)propanoic acid (34840-85-2,54160-62-2,34841-09-3,54160-63-3)

Guidance literature:

With ammonium acetate; In ethanol; water; at 80 ℃; for 16h;

Reference yield: 78.0%

malonic acid (141-82-2) + 3,4-dimethoxy-benzaldehyde (120-14-9) → 3-amino-3-(3,4-dimethoxyphenyl)propanoic acid (34840-85-2,54160-62-2,34841-09-3,54160-63-3)

Guidance literature:

With ammonium formate; In ethanol; for 6h; Reflux;

DOI:10.1039/c1cc11528f

Reference yield: 56.0%

3,4-dimethoxy-benzaldehyde (120-14-9) → 3-amino-3-(3,4-dimethoxyphenyl)propanoic acid (34840-85-2,54160-62-2,34841-09-3,54160-63-3)

Guidance literature:

With ammonium acetate; malonic acid; In ethanol;

upstream raw materials:

malonic acid

3,4-dimethoxy-benzaldehyde

C₉H₁₁NO₂

3,4-dimethoxybenzylamine

Downstream raw materials:

3-phthalimido-3-(3',4'-dimethoxyphenyl)propionic acid

methyl 3-amino-3-(3,4-dimethoxyphenyl)propionate

(R)-3-amino-3-(3,4-dihydroxyphenyl)propanoic acid hydrochloride

(R)-3-amino-3-(3,4-dimethoxyphenyl)propanoic acid

Refernces

• 1、 -. "ISOINDOLE DERIVATIVE". Paragraph 0228; 0234. . Retrieved 2021/02/25.
• 2、 Adams, James,Anderson, Edward C.,Blackham, Emma E.,Chiu, Yin Wa Ryan,Clarke, Thomas,Eccles, Natasha,Gill, Luke A.,Haye, Joshua J.,Haywood, Harvey T.,Hoenig, Christian R.,Kausas, Marius,Le, Joelle,Russell, Hannah L.,Smedley, Christopher,Tipping, William J.,Tongue, Tom,Wood, Charlotte C.,Yeung, Jason,Rowedder, James E.,Fray, M. Jonathan,McInally, Thomas,Macdonald, Simon J. F.. "Structure activity relationships of αv integrin antagonists for pulmonary fibrosis by variation in aryl substituents". supporting information. p. 1207 - 1212. Retrieved 2015/04/27.