tert-butyl (E)-3-(6-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-pyridin-2-yl)-acrylate

Base Information

• Chemical Name: tert-butyl (E)-3-(6-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-pyridin-2-yl)-acrylate
• CAS No.: 1123622-51-4
• Molecular Formula: C₂₆H₃₁N₃O₃
• Molecular Weight: 433.55
• Mol file: 1123622-51-4.mol

Synonyms:tert-butyl (E)-3-(6-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-pyridin-2-yl)-acrylate

Chemical Property of tert-butyl (E)-3-(6-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-pyridin-2-yl)-acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (E)-3-(6-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-pyridin-2-yl)-acrylate

There total 6 articles about tert-butyl (E)-3-(6-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-pyridin-2-yl)-acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1-[2-(4-methylpiperazin-1-yl)phenyl]ethanone (56915-77-6) + (E)-3-(6-formylpyridin-2-yl)acrylic acid tert-butyl ester (1123622-32-1) → tert-butyl (E)-3-(6-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-pyridin-2-yl)-acrylate (1123622-51-4)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm901502p

Reference yield:

6-bromo-2-pyridinecarbaldehyde (34160-40-2) → tert-butyl (E)-3-(6-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-pyridin-2-yl)-acrylate (1123622-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane; tetrabutylammomium bromide; potassium carbonate / palladium diacetate / N,N-dimethyl-formamide / 5 h / 120 °C / Microwave irradiation

2: potassium hydroxide / tetrahydrofuran / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; potassium hydroxide; tetrabutylammomium bromide; potassium carbonate; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

tert-Butyl acrylate (1663-39-4,25232-27-3) → tert-butyl (E)-3-(6-{(E)-3-[2-(4-methyl-piperazin-1-yl)-phenyl]-3-oxo-propenyl}-pyridin-2-yl)-acrylate (1123622-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane; tetrabutylammomium bromide; potassium carbonate / palladium diacetate / N,N-dimethyl-formamide / 5 h / 120 °C / Microwave irradiation

2: potassium hydroxide / tetrahydrofuran / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; potassium hydroxide; tetrabutylammomium bromide; potassium carbonate; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

1-[2-(4-methylpiperazin-1-yl)phenyl]ethanone

(E)-3-(6-formylpyridin-2-yl)acrylic acid tert-butyl ester

1-methyl-piperazine

6-bromo-2-pyridinecarbaldehyde

Downstream raw materials:

C₂₂H₂₃N₃O₃