4-bromo-2-methoxyphenyl benzyl ketone

Base Information

• Chemical Name: 4-bromo-2-methoxyphenyl benzyl ketone
• CAS No.: 250675-82-2
• Molecular Formula: C₁₅H₁₃BrO₂
• Molecular Weight: 305.171
• Mol file: 250675-82-2.mol

Synonyms:4-bromo-2-methoxyphenyl benzyl ketone

Chemical Property of 4-bromo-2-methoxyphenyl benzyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-2-methoxyphenyl benzyl ketone

There total 1 articles about 4-bromo-2-methoxyphenyl benzyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

phenylacetic acid (103-82-2) + 1-bromo-4-methoxy-benzene (104-92-7) → 4-bromo-2-methoxyphenyl benzyl ketone (250675-82-2)

Guidance literature:

With PPA; at 60 ℃;

DOI:10.1016/S0040-4020(99)00652-3

Reference yield: 55.0%

4-bromo-2-methoxyphenyl benzyl ketone (250675-82-2) → 4-bromo-2-methoxy-α-phenyl-α-diazoacetophenone (250675-85-5)

Guidance literature:

4-bromo-2-methoxyphenyl benzyl ketone; With sodium ethanolate; In ethanol; at 0 ℃; for 0.5h;

With 4-toluenesulfonyl azide; In ethanol; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4020(99)00652-3

Reference yield:

4-bromo-2-methoxyphenyl benzyl ketone (250675-82-2) → 5-bromo-2-phenylcoumaranone

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium ethoxide / ethanol / 0.5 h / 0 °C

1.2: 55 percent / tosyl azide / ethanol / 0.5 h / 0 °C

2.1: 66 percent / perchloric acid / CH₂Cl₂ / 0.25 h / -10 °C

With perchloric acid; sodium ethanolate; In ethanol; dichloromethane; 1.1: Metallation / 1.2: Condensation / 2.1: Cyclization;

DOI:10.1016/S0040-4020(99)00652-3

upstream raw materials:

phenylacetic acid

1-bromo-4-methoxy-benzene

Downstream raw materials:

4-bromo-2-methoxy-α-phenyl-α-diazoacetophenone