3-(4-Fluoro-phenoxy)-2,2-dimethyl-2,2a-dihydro-1H-cyclobuta[a]naphthalen-8b-ol

Base Information

Chemical Name:3-(4-Fluoro-phenoxy)-2,2-dimethyl-2,2a-dihydro-1H-cyclobuta[a]naphthalen-8b-ol
CAS No.:72035-63-3
Molecular Formula:C₂₀H₁₉FO₂
Molecular Weight:310.368
Hs Code.:

Synonyms:3-(4-Fluoro-phenoxy)-2,2-dimethyl-2,2a-dihydro-1H-cyclobuta[a]naphthalen-8b-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(4-Fluoro-phenoxy)-2,2-dimethyl-2,2a-dihydro-1H-cyclobuta[a]naphthalen-8b-ol

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Technology Process of 3-(4-Fluoro-phenoxy)-2,2-dimethyl-2,2a-dihydro-1H-cyclobuta[a]naphthalen-8b-ol

There total 2 articles about 3-(4-Fluoro-phenoxy)-2,2-dimethyl-2,2a-dihydro-1H-cyclobuta[a]naphthalen-8b-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 108-86-1,52753-63-6
bromobenzene

: 72035-58-6
3-(4-Fluoro-phenoxy)-5,5-dimethyl-cyclohex-2-enone

: 72035-63-3
3-(4-Fluoro-phenoxy)-2,2-dimethyl-2,2a-dihydro-1H-cyclobuta[a]naphthalen-8b-ol

Guidance literature:: With sodium amide; In tetrahydrofuran; at 30 ℃; for 3h;
DOI:10.1021/jo01290a007

Reference yield:

: 371-41-5
4-Fluorophenol

: 72035-63-3
3-(4-Fluoro-phenoxy)-2,2-dimethyl-2,2a-dihydro-1H-cyclobuta[a]naphthalen-8b-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / 1.) NaOH, 2.)Bu₄NCl / 1.) H₂O, 2.) benzene, reflux

2: 55 percent / NaNH₂ / tetrahydrofuran / 3 h / 30 °C

With sodium hydroxide; tetrabutyl-ammonium chloride; sodium amide; In tetrahydrofuran;
DOI:10.1021/jo01290a007

Reference yield: 55.0%

: 72035-63-3
3-(4-Fluoro-phenoxy)-2,2-dimethyl-2,2a-dihydro-1H-cyclobuta[a]naphthalen-8b-ol

: 72035-69-9
(E)-9-(4-Fluoro-phenoxy)-7,7-dimethyl-7,8-dihydro-6H-benzocycloocten-5-one

Guidance literature:: With sodium hydride; In 1,2-dimethoxyethane; for 4h; Further byproducts given; Ambient temperature;
DOI:10.1021/jo01290a007