tert-butyl ((trans)-4-((5-chloro-3-(((2,6-dimethyl-4-oxo-4H-pyran-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

Base Information

Chemical Name:tert-butyl ((trans)-4-((5-chloro-3-(((2,6-dimethyl-4-oxo-4H-pyran-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate
CAS No.:1617501-29-7
Molecular Formula:C₂₉H₄₀ClN₃O₅
Molecular Weight:546.107
Hs Code.:

Synonyms:tert-butyl ((trans)-4-((5-chloro-3-(((2,6-dimethyl-4-oxo-4H-pyran-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

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Chemical Property of tert-butyl ((trans)-4-((5-chloro-3-(((2,6-dimethyl-4-oxo-4H-pyran-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

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Technology Process of tert-butyl ((trans)-4-((5-chloro-3-(((2,6-dimethyl-4-oxo-4H-pyran-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

There total 7 articles about tert-butyl ((trans)-4-((5-chloro-3-(((2,6-dimethyl-4-oxo-4H-pyran-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403596-81-5
C₂₁H₃₁ClN₂O₄

: 1617501-42-4
3-(aminomethyl)-2,6-dimethyl-4H-pyran-4-one hydrochloride

: 1617501-29-7
tert-butyl ((trans)-4-((5-chloro-3-(((2,6-dimethyl-4-oxo-4H-pyran-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

Guidance literature:: With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

: 1617501-27-5
2-((2,6-dimethyl-4-oxo-4H-pyran-3-yl)methyl)isoindoline-1,3-dione

: 1617501-29-7
tert-butyl ((trans)-4-((5-chloro-3-(((2,6-dimethyl-4-oxo-4H-pyran-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 1.5 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With 4-methyl-morpholine; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 179321-49-4
N-(tert-butoxycarbonyl)-4-aminocyclohexanone

: 1617501-29-7
tert-butyl ((trans)-4-((5-chloro-3-(((2,6-dimethyl-4-oxo-4H-pyran-3-yl)methyl)carbamoyl)-2-methylphenyl)(ethyl)amino)cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc(II) chloride / methanol / 2 h / 20 °C

1.2: 24 h / 40 °C

2.1: acetic acid / 1,2-dichloro-ethane / 1 h / 20 °C

2.2: 0 - 20 °C

3.1: methanol; sodium hydroxide / 8 h / 70 °C

4.1: 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With 4-methyl-morpholine; methanol; 1-hydroxy-7-aza-benzotriazole; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; zinc(II) chloride; In methanol; dichloromethane; 1,2-dichloro-ethane;