(1S,2R)-2-[(6-amino-9H-purin-9-yl)methyl]-1-benzyloxycarbonylamino-2-hydroxymethylcyclopropane

Base Information

Chemical Name:(1S,2R)-2-[(6-amino-9H-purin-9-yl)methyl]-1-benzyloxycarbonylamino-2-hydroxymethylcyclopropane
CAS No.:250225-70-8
Molecular Formula:C₁₈H₂₀N₆O₃
Molecular Weight:368.395
Hs Code.:

Synonyms:(1S,2R)-2-[(6-amino-9H-purin-9-yl)methyl]-1-benzyloxycarbonylamino-2-hydroxymethylcyclopropane

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Chemical Property of (1S,2R)-2-[(6-amino-9H-purin-9-yl)methyl]-1-benzyloxycarbonylamino-2-hydroxymethylcyclopropane

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Technology Process of (1S,2R)-2-[(6-amino-9H-purin-9-yl)methyl]-1-benzyloxycarbonylamino-2-hydroxymethylcyclopropane

There total 4 articles about (1S,2R)-2-[(6-amino-9H-purin-9-yl)methyl]-1-benzyloxycarbonylamino-2-hydroxymethylcyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 250225-69-5
methyl (1S,2R)-2-[(6-amino-9H-purin-9-yl)methyl]-1-(benzyloxycarbonylamino)cyclopropanecarboxylate

: 250225-70-8
(1S,2R)-2-[(6-amino-9H-purin-9-yl)methyl]-1-benzyloxycarbonylamino-2-hydroxymethylcyclopropane

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 20h;
DOI:10.1021/jo025599v

Reference yield:

: 175694-64-1
methyl (1S,2R)-(-)-1-N-benzyloxycarbonylamino-2-methanesulfonyloxymethylcyclopropanecarboxylate

: 250225-70-8
(1S,2R)-2-[(6-amino-9H-purin-9-yl)methyl]-1-benzyloxycarbonylamino-2-hydroxymethylcyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent / potassium carbonate; 18-crown-6 / dimethylformamide / 10 h / 80 °C

2: 70 percent / LiBH₄

With lithium borohydride; 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/ol990203w

Reference yield:

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 250225-70-8
(1S,2R)-2-[(6-amino-9H-purin-9-yl)methyl]-1-benzyloxycarbonylamino-2-hydroxymethylcyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent / potassium carbonate; 18-crown-6 / dimethylformamide / 10 h / 80 °C

2: 70 percent / LiBH₄

With lithium borohydride; 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/ol990203w