(2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)propyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Base Information

Chemical Name:(2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)propyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine
CAS No.:156365-89-8
Molecular Formula:C₂₄H₃₁NO₄
Molecular Weight:397.514
Hs Code.:

Synonyms:(2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)propyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)propyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

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Technology Process of (2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)propyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

There total 4 articles about (2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)propyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 925-90-6
ethylmagnesium bromide

: 156365-81-0
(2S,4S,5R)-4-methyl-2-(1-oxo-1-phenyl)methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

: 156365-89-8
(2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)propyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Guidance literature:: In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0040-4039(00)76893-6

Reference yield:

: 1074-12-0
phenylglyoxal hydrate

: 156365-89-8
(2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)propyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: molecular sieves 4A / CH₂Cl₂ / 0.5 h / Ambient temperature

2: ethyl acetate / 1.5 h / Heating

3: 53 percent / tetrahydrofuran / 0 °C

With 4 A molecular sieve; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4039(00)76893-6

Reference yield:

: 492-41-1,58550-13-3,757124-50-8
(1R,2S)-norephedrine

: 156365-89-8
(2S,4S,5R)-2-(1R)-(1-hydroxy-1-phenyl)propyl-4-methyl-5-phenyl-3-tert-butoxycarbonyloxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: molecular sieves 4A / CH₂Cl₂ / 0.5 h / Ambient temperature

2: ethyl acetate / 1.5 h / Heating

3: 53 percent / tetrahydrofuran / 0 °C

With 4 A molecular sieve; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4039(00)76893-6