(E)-{4-[2-(2-(((tert-butoxy)carbonyl)amino)phenylcarbamoyl)vinyl]phenyl}hydroxyacetic acid methyl ester

Base Information

Chemical Name:(E)-{4-[2-(2-(((tert-butoxy)carbonyl)amino)phenylcarbamoyl)vinyl]phenyl}hydroxyacetic acid methyl ester
CAS No.:1174571-68-6
Molecular Formula:C₂₃H₂₆N₂O₆
Molecular Weight:426.469
Hs Code.:

Synonyms:(E)-{4-[2-(2-(((tert-butoxy)carbonyl)amino)phenylcarbamoyl)vinyl]phenyl}hydroxyacetic acid methyl ester

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Chemical Property of (E)-{4-[2-(2-(((tert-butoxy)carbonyl)amino)phenylcarbamoyl)vinyl]phenyl}hydroxyacetic acid methyl ester

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Technology Process of (E)-{4-[2-(2-(((tert-butoxy)carbonyl)amino)phenylcarbamoyl)vinyl]phenyl}hydroxyacetic acid methyl ester

There total 5 articles about (E)-{4-[2-(2-(((tert-butoxy)carbonyl)amino)phenylcarbamoyl)vinyl]phenyl}hydroxyacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 503039-31-4
N-(2-(acryloylamino)phenyl)carbamic acid tert-butyl ester

: 127709-20-0
α-hydroxy-(p-bromophenyl)-acetic acid methyl ester

: 1174571-68-6
(E)-{4-[2-(2-(((tert-butoxy)carbonyl)amino)phenylcarbamoyl)vinyl]phenyl}hydroxyacetic acid methyl ester

Guidance literature:: With triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 100 ℃; for 6h; Inert atmosphere;

Reference yield:

: 6940-50-7
4-bromo-DL-mandelic acid

: 1174571-68-6
(E)-{4-[2-(2-(((tert-butoxy)carbonyl)amino)phenylcarbamoyl)vinyl]phenyl}hydroxyacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 3 h / 50 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 6 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; triethylamine; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; 2: |Heck Reaction;
DOI:10.1021/jm3011838

Reference yield:

: 95-54-5
1,2-diamino-benzene

: 1174571-68-6
(E)-{4-[2-(2-(((tert-butoxy)carbonyl)amino)phenylcarbamoyl)vinyl]phenyl}hydroxyacetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 16 h / 20 °C

2.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.5 h / 0 °C

2.2: 2.5 h / Reflux

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 6 h / 100 °C / Inert atmosphere

With 4-methyl-morpholine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; tris-(o-tolyl)phosphine; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3.1: |Heck Reaction;
DOI:10.1021/jm3011838