1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<(3-phenylpropoxy)methyl>piperidine hydrochloride

Base Information

Chemical Name:1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<(3-phenylpropoxy)methyl>piperidine hydrochloride
CAS No.:137650-41-0
Molecular Formula:C₂₆H₃₆N₂O₃*ClH
Molecular Weight:461.044
Hs Code.:

Synonyms:1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<(3-phenylpropoxy)methyl>piperidine hydrochloride

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Chemical Property of 1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<(3-phenylpropoxy)methyl>piperidine hydrochloride

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Technology Process of 1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<(3-phenylpropoxy)methyl>piperidine hydrochloride

There total 7 articles about 1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<(3-phenylpropoxy)methyl>piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {(S)-1-(4-Hydroxy-2,6-dimethyl-benzyl)-2-oxo-2-[2-(3-phenyl-propoxymethyl)-piperidin-1-yl]-ethyl}-carbamic acid tert-butyl ester

: 137650-41-0
1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<(3-phenylpropoxy)methyl>piperidine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 23 ℃; for 0.166667h; Yield given;
DOI:10.1021/jm00080a005

Reference yield:

: 137650-02-3,85387-43-5
(1-benzylpiperidin-2-yl)methanol

: 137650-41-0
1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<(3-phenylpropoxy)methyl>piperidine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, a.) RT, 1 h, b.) 50 deg C, 2 h, 2.) THF, a.) 40 deg C, 16 h, b.) reflux, 2 h

2: 55 percent / H₂, acetic acid / 10percent Pd/C / ethanol / 50 °C / 3102.9 Torr

3: 4-methylmorpholine / CH₂Cl₂ / 1.5 h

4: 6.5N HCl / dioxane; CH₂Cl₂ / 0.17 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; sodium hydride; acetic acid; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jm00080a005

Reference yield:

: 69804-99-5
3-phenylpropanol methanesulfonate

: 137650-41-0
1-<2(S)-amino-3-(4-hydroxy-2,6-dimethylphenyl)-1-oxopropyl>-2-<(3-phenylpropoxy)methyl>piperidine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, a.) RT, 1 h, b.) 50 deg C, 2 h, 2.) THF, a.) 40 deg C, 16 h, b.) reflux, 2 h

2: 55 percent / H₂, acetic acid / 10percent Pd/C / ethanol / 50 °C / 3102.9 Torr

3: 4-methylmorpholine / CH₂Cl₂ / 1.5 h

4: 6.5N HCl / dioxane; CH₂Cl₂ / 0.17 h / 23 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; sodium hydride; acetic acid; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jm00080a005