(2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride

Base Information

Chemical Name:(2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride
CAS No.:173399-03-6
Molecular Formula:C30H53 N3 O6 . Cl H
Molecular Weight:588.228
Hs Code.:
Mol file:173399-03-6.mol

(2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride

Synonyms:Benzeneoctanamide,d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-g-hydroxy-4-methoxy-3-(3-methoxypropoxy)-a,z-bis(1-methylethyl)-, monohydrochloride, (aS,gS,dS,zS)- (9CI); Benzeneoctanamide, d-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-g-hydroxy-4-methoxy-3-(3-methoxypropoxy)-a,z-bis(1-methylethyl)-, monohydrochloride, [aS-(aR*,gR*,dR*,zR*)]-

Suppliers and Price of (2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AliskirenHydrochloride
2mg
$ 395.00

Medical Isotopes, Inc.
Aliskirenhydrochloride
1 mg
$ 725.00

Biosynth Carbosynth
Aliskiren hydrochloride
1 mg
$ 408.80

Biosynth Carbosynth
Aliskiren hydrochloride
25 mg
$ 5500.00

Biosynth Carbosynth
Aliskiren hydrochloride
10 mg
$ 2457.00

Biosynth Carbosynth
Aliskiren hydrochloride
5 mg
$ 1351.40

Biosynth Carbosynth
Aliskiren hydrochloride
2 mg
$ 743.30

Total 14 raw suppliers

Chemical Property of (2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride

Chemical Property:

Melting Point:76-78°C
PSA：146.13000
LogP:5.88700
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility.:Chloroform, Methanol

Purity/Quality:

99% ^*data from raw suppliers

AliskirenHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride

There total 10 articles about (2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 173338-07-3
tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate

: 173399-03-6
aliskiren

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; Inert atmosphere;
DOI:10.1021/jo5015195

Reference yield: 82.0%

: 325154-31-2
(2S,4S,5R,7S)-5-Azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide

: 173399-03-6
aliskiren

Guidance literature:: (2S,4S,5R,7S)-5-Azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide; With palladium 10% on activated carbon; hydrogen; In methanol; ethanolamine; at 20 ℃; for 3h;

With hydrogenchloride; In methanol;
DOI:10.1039/c4ob01963f

Reference yield:

: (3S,8S,9R)-3,8-diisopropyl-9-(4-methoxy-3-(3-methoxypropoxy)-phenyl)-4,7,8,9-tetrahydro-3H-oxonin-2-one

: 173399-03-6
aliskiren

Guidance literature:: Multi-step reaction with 7 steps

1.1: magnesium oxide; Rh₂(tfacam)₄; [bis(acetoxy)iodo]benzene / toluene / 16 h / 0 - 25 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.1: triethylamine; 2-hydroxypyridin / 72 h / 85 °C / Inert atmosphere

4.1: acetic acid; zinc copper / methanol / 16 h / 20 °C / Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

5.1: potassium carbonate; tetrabutylammomium bromide / dichloromethane; water / 16 h / 0 - 20 °C / Inert atmosphere

6.1: sodium; ammonia / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane / Inert atmosphere

With 2-hydroxypyridin; hydrogenchloride; zinc copper; [bis(acetoxy)iodo]benzene; Rh₂(tfacam)₄; tetrabutylammomium bromide; ammonia; sodium; magnesium oxide; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene;
DOI:10.1021/jo5015195