6-broMo-1-tert-butyl-1H-benzo[d]iMidazole

Base Information

• Chemical Name: 6-broMo-1-tert-butyl-1H-benzo[d]iMidazole
• CAS No.: 1163707-71-8
• Molecular Formula: C₁₁H₁₃BrN₂
• Molecular Weight: 253.142
• Mol file: 1163707-71-8.mol

Synonyms:6-bromo-1-(tert-butyl)-1H-benzo[d]imidazole

Chemical Property of 6-broMo-1-tert-butyl-1H-benzo[d]iMidazole

Chemical Property:

• Boiling Point: 334.9±34.0 °C(Predicted)
• PKA: 4.78±0.10(Predicted)
• Density: 1.37±0.1 g/cm3(Predicted)

Purity/Quality:

98%min ^*data from raw suppliers

6-Bromo-1-tert-butyl-1H-benzo[d]imidazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-broMo-1-tert-butyl-1H-benzo[d]iMidazole

There total 1 articles about 6-broMo-1-tert-butyl-1H-benzo[d]iMidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2-fluoronitrobenzene (321-23-3) → 6-bromo-1-(tert-butyl)-1H-benzo[d]imidazole (1163707-71-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2.1: ammonium chloride / methanol / 0.25 h / 70 °C

2.2: 4 h / 70 °C

3.1: 2 h / 70 °C

With potassium carbonate; ammonium chloride; In methanol; N,N-dimethyl-formamide;

Reference yield:

6-bromo-1-(tert-butyl)-1H-benzo[d]imidazole (1163707-71-8) → C31H30N6O2

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium acetate / N,N-dimethyl-formamide; acetonitrile / 0.08 h / Sonication

1.2: 10 h / 80 °C / Inert atmosphere

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / acetonitrile; water / 0.67 h / 100 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium carbonate; In water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

4-bromo-2-fluoronitrobenzene

Refernces

• 1、 -. "COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR". . . Retrieved 2016/11/24.