(S)-2-(1-hydroxy-3-methylbut-2-ylamino)-6-[4-(2-pyrimidinyl)phenylamino]-9-isopropylpurine

Base Information

Chemical Name:(S)-2-(1-hydroxy-3-methylbut-2-ylamino)-6-[4-(2-pyrimidinyl)phenylamino]-9-isopropylpurine
CAS No.:1415505-26-8
Molecular Formula:C₂₃H₂₈N₈O
Molecular Weight:432.528
Hs Code.:

Synonyms:(S)-2-(1-hydroxy-3-methylbut-2-ylamino)-6-[4-(2-pyrimidinyl)phenylamino]-9-isopropylpurine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(1-hydroxy-3-methylbut-2-ylamino)-6-[4-(2-pyrimidinyl)phenylamino]-9-isopropylpurine

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Technology Process of (S)-2-(1-hydroxy-3-methylbut-2-ylamino)-6-[4-(2-pyrimidinyl)phenylamino]-9-isopropylpurine

There total 4 articles about (S)-2-(1-hydroxy-3-methylbut-2-ylamino)-6-[4-(2-pyrimidinyl)phenylamino]-9-isopropylpurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 2026-48-4,473-75-6
(S)-valinol

: 1415505-19-9
2-chloro-6-[4-(2-pyrimidinyl)phenylamino]-9-isopropylpurine

: 1415505-26-8
(S)-2-(1-hydroxy-3-methylbut-2-ylamino)-6-[4-(2-pyrimidinyl)phenylamino]-9-isopropylpurine

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 150 ℃;
DOI:10.1007/s00044-012-0334-1

Reference yield:

: 203436-45-7
2,6-dichloro-9-isopropyl-9H-purine

: 1415505-26-8
(S)-2-(1-hydroxy-3-methylbut-2-ylamino)-6-[4-(2-pyrimidinyl)phenylamino]-9-isopropylpurine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / butan-1-ol / 24 h / 100 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 100 °C / Inert atmosphere

3: triethylamine / dimethyl sulfoxide / 150 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; In 1,4-dioxane; water; dimethyl sulfoxide; butan-1-ol; 2: |Suzuki Coupling;
DOI:10.1007/s00044-012-0334-1

Reference yield:

: 5451-40-1
2,6 dichloropurine

: 1415505-26-8
(S)-2-(1-hydroxy-3-methylbut-2-ylamino)-6-[4-(2-pyrimidinyl)phenylamino]-9-isopropylpurine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 120 h / 15 - 18 °C

2: triethylamine / butan-1-ol / 24 h / 100 °C

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 100 °C / Inert atmosphere

4: triethylamine / dimethyl sulfoxide / 150 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; triethylamine; In 1,4-dioxane; water; dimethyl sulfoxide; butan-1-ol; 3: |Suzuki Coupling;
DOI:10.1007/s00044-012-0334-1