1-[2-chloro-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-6-methyl-4-trifluoromethyl-1H-pyrimidin-2-one

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Chemical Name:1-[2-chloro-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-6-methyl-4-trifluoromethyl-1H-pyrimidin-2-one
CAS No.:1070973-23-7
Molecular Formula:C₂₂H₁₉ClF₃N₃O₃S
Molecular Weight:497.925
Hs Code.:

Synonyms:1-[2-chloro-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-6-methyl-4-trifluoromethyl-1H-pyrimidin-2-one

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Chemical Property of 1-[2-chloro-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-6-methyl-4-trifluoromethyl-1H-pyrimidin-2-one

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Technology Process of 1-[2-chloro-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-6-methyl-4-trifluoromethyl-1H-pyrimidin-2-one

There total 5 articles about 1-[2-chloro-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-6-methyl-4-trifluoromethyl-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 367-57-7
1,1,1-Trifluoro-2,4-pentanedione

: 1070973-24-8
[2-chloro-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-urea

: 1070973-23-7
1-[2-chloro-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-6-methyl-4-trifluoromethyl-1H-pyrimidin-2-one

Guidance literature:: 1,1,1-Trifluoro-2,4-pentanedione; [2-chloro-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-urea; With sulfuric acid; In ethanol; at 80 ℃; for 6h;

With sodium hydroxide; In ethanol; water;

Reference yield:

: 1701-57-1
2,3,4,5-tetrahydro-1Hbenzo[b]azepine

: 1070973-23-7
1-[2-chloro-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-6-methyl-4-trifluoromethyl-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C

2.1: sodium dithionite / tetrahydrofuran; water / 2 h / 20 °C

3.1: 1,1-dichloroethane; acetic acid / 24 h / 100 °C

3.2: pH 8

4.1: sulfuric acid / ethanol / 6 h / 80 °C

With sodium dithionite; sulfuric acid; triethylamine; In tetrahydrofuran; 1,1-dichloroethane; ethanol; dichloromethane; water; acetic acid;

Reference yield:

: 847171-37-3
2-chloro-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenylamine

: 1070973-23-7
1-[2-chloro-5-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenyl]-6-methyl-4-trifluoromethyl-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,1-dichloroethane; acetic acid / 24 h / 100 °C

1.2: pH 8

2.1: sulfuric acid / ethanol / 6 h / 80 °C

With sulfuric acid; In 1,1-dichloroethane; ethanol; acetic acid;