Technology Process of 4-(4′-aminophenyl)-3-ethoxy-1,2,5-oxadiazole
There total 4 articles about 4-(4′-aminophenyl)-3-ethoxy-1,2,5-oxadiazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodiumsulfide nonahydrate;
In
1,4-dioxane; water;
at 80 ℃;
for 0.75h;
Inert atmosphere;
DOI:10.1016/j.bmc.2014.02.013
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 6 h / Reflux; Inert atmosphere
2.1: sodium acetate / ethanol / 120 h / Reflux; Inert atmosphere
3.1: acetic acid; sodium nitrite; hydrogenchloride / water / 0.5 h / 0 °C / Inert atmosphere
3.2: 0.08 h / 0 °C / Inert atmosphere
4.1: sodium / 2 h / 20 °C
5.1: sodiumsulfide nonahydrate / 1,4-dioxane; water / 0.75 h / 80 °C / Inert atmosphere
With
hydrogenchloride; sodiumsulfide nonahydrate; hydroxylamine hydrochloride; sodium acetate; sodium; acetic acid; sodium nitrite;
In
1,4-dioxane; ethanol; water;
DOI:10.1016/j.bmc.2014.02.013
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetic acid; sodium nitrite; hydrogenchloride / water / 0.5 h / 0 °C / Inert atmosphere
1.2: 0.08 h / 0 °C / Inert atmosphere
2.1: sodium / 2 h / 20 °C
3.1: sodiumsulfide nonahydrate / 1,4-dioxane; water / 0.75 h / 80 °C / Inert atmosphere
With
hydrogenchloride; sodiumsulfide nonahydrate; sodium; acetic acid; sodium nitrite;
In
1,4-dioxane; water;
DOI:10.1016/j.bmc.2014.02.013
