(phenylacetyl)-L-histidyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

Base Information

Chemical Name:(phenylacetyl)-L-histidyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine
CAS No.:126082-57-3
Molecular Formula:C₃₈H₅₅N₇O₅
Molecular Weight:689.899
Hs Code.:

Synonyms:(phenylacetyl)-L-histidyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

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Chemical Property of (phenylacetyl)-L-histidyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

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Technology Process of (phenylacetyl)-L-histidyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

There total 6 articles about (phenylacetyl)-L-histidyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 126082-58-4
(phenylacetyl)-N^im-tosyl-L-histidyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

: 126082-57-3
(phenylacetyl)-L-histidyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

Guidance literature:: With benzotriazol-1-ol; In methanol; Ambient temperature;
DOI:10.1021/jm00167a009

Reference yield:

: 103-82-2
phenylacetic acid

: 126082-57-3
(phenylacetyl)-L-histidyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂; dimethylformamide / Ambient temperature

2: 52 percent / 1-hydroxybenzotriazole (1-HOBT) / methanol / Ambient temperature

With diethylphosphoryl cyanide; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a009

Reference yield:

: 103372-32-3
N-α-<4(S)-<(tert-butyldimethylsilyl)oxy>-5(S)-<(tert-butyloxycarbonyl)amino>-2(S)-isopropyl-7-methyloctanoyl>-L-isoleucyl>-2-pyridylmethylamine

: 126082-57-3
(phenylacetyl)-L-histidyl-5(S)-amino-4(S)-hydroxy-2(S)-isopropyl-7-(methyloctanoyl)-L-isoleucyl-2-pyridylmethylamine

Guidance literature:: Multi-step reaction with 5 steps

1: HCl (gas) / diethyl ether / 0.25 h

2: diethylphosphoryl cyanide (DEPC), Et₃N / CH₂Cl₂

3: 50 mg / trifluoroacetic acid (TFA) / CH₂Cl₂ / 0.75 h

4: 86 percent / diisopropylethylamine, diethylphosphoryl cyanide (DEPC) / CH₂Cl₂; dimethylformamide / Ambient temperature

5: 52 percent / 1-hydroxybenzotriazole (1-HOBT) / methanol / Ambient temperature

With hydrogenchloride; diethylphosphoryl cyanide; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00167a009