4-[(1S,2R)-2-(Bis-benzyloxy-thiophosphoryloxy)-1-methylcarbamoyl-propylcarbamoyl]-butyric acid tert-butyl ester

Base Information

Chemical Name:4-[(1S,2R)-2-(Bis-benzyloxy-thiophosphoryloxy)-1-methylcarbamoyl-propylcarbamoyl]-butyric acid tert-butyl ester
CAS No.:851983-98-7
Molecular Formula:C₂₈H₃₉N₂O₇PS
Molecular Weight:578.667
Hs Code.:

Synonyms:4-[(1S,2R)-2-(Bis-benzyloxy-thiophosphoryloxy)-1-methylcarbamoyl-propylcarbamoyl]-butyric acid tert-butyl ester

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Chemical Property of 4-[(1S,2R)-2-(Bis-benzyloxy-thiophosphoryloxy)-1-methylcarbamoyl-propylcarbamoyl]-butyric acid tert-butyl ester

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Technology Process of 4-[(1S,2R)-2-(Bis-benzyloxy-thiophosphoryloxy)-1-methylcarbamoyl-propylcarbamoyl]-butyric acid tert-butyl ester

There total 6 articles about 4-[(1S,2R)-2-(Bis-benzyloxy-thiophosphoryloxy)-1-methylcarbamoyl-propylcarbamoyl]-butyric acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[(1S,2R)-2-(Bis-benzyloxy-phosphoryloxy)-1-methylcarbamoyl-propylcarbamoyl]-butyric acid tert-butyl ester

: 851983-98-7
4-[(1S,2R)-2-(Bis-benzyloxy-thiophosphoryloxy)-1-methylcarbamoyl-propylcarbamoyl]-butyric acid tert-butyl ester

Guidance literature:: With 3-phenylethanoic dithioperoxyanhydride; In 1,4-dioxane; at 23 ℃; for 2h;
DOI:10.1021/ja050727t

Reference yield:

: 863480-63-1
4-((1S,2R)-2-Benzyloxy-1-methylcarbamoyl-propylcarbamoyl)-butyric acid

: 851983-98-7
4-[(1S,2R)-2-(Bis-benzyloxy-thiophosphoryloxy)-1-methylcarbamoyl-propylcarbamoyl]-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.09 g / H₂SO₄ / CH₂Cl₂ / 20 °C

2: 84 percent / H₂ / Pd/C / methanol / 72 h

3: tetrazole / dioxane / 2 h / 23 °C

4: 0.314 g / phenylacetyl disulfide / dioxane / 2 h / 23 °C

With 1H-tetrazole; sulfuric acid; 3-phenylethanoic dithioperoxyanhydride; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/ja050727t

Reference yield:

: 851983-96-5
4-((1S,2R)-2-Benzyloxy-1-methylcarbamoyl-propylcarbamoyl)-butyric acid tert-butyl ester

: 851983-98-7
4-[(1S,2R)-2-(Bis-benzyloxy-thiophosphoryloxy)-1-methylcarbamoyl-propylcarbamoyl]-butyric acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / H₂ / Pd/C / methanol / 72 h

2: tetrazole / dioxane / 2 h / 23 °C

3: 0.314 g / phenylacetyl disulfide / dioxane / 2 h / 23 °C

With 1H-tetrazole; 3-phenylethanoic dithioperoxyanhydride; hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol;
DOI:10.1021/ja050727t