Benzhydrylidene-{3-chloro-4-[2-cyclopropyl-2-(4-methoxy-phenylamino)-ethyl]-phenyl}-amine

Base Information

Chemical Name:Benzhydrylidene-{3-chloro-4-[2-cyclopropyl-2-(4-methoxy-phenylamino)-ethyl]-phenyl}-amine
CAS No.:608131-24-4
Molecular Formula:C₃₁H₂₉ClN₂O
Molecular Weight:481.037
Hs Code.:

Synonyms:Benzhydrylidene-{3-chloro-4-[2-cyclopropyl-2-(4-methoxy-phenylamino)-ethyl]-phenyl}-amine

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Chemical Property of Benzhydrylidene-{3-chloro-4-[2-cyclopropyl-2-(4-methoxy-phenylamino)-ethyl]-phenyl}-amine

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Technology Process of Benzhydrylidene-{3-chloro-4-[2-cyclopropyl-2-(4-methoxy-phenylamino)-ethyl]-phenyl}-amine

There total 4 articles about Benzhydrylidene-{3-chloro-4-[2-cyclopropyl-2-(4-methoxy-phenylamino)-ethyl]-phenyl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1013-88-3
Benzophenone imine

: 608131-12-0
[2-(4-bromo-2-chloro-phenyl)-1-cyclopropyl-ethyl]-(4-methoxy-phenyl)-amine

: 608131-24-4
Benzhydrylidene-{3-chloro-4-[2-cyclopropyl-2-(4-methoxy-phenylamino)-ethyl]-phenyl}-amine

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; at 100 ℃; for 24h;
DOI:10.1002/ejoc.200300123

Reference yield:

: 31928-47-9
4-bromo-2-chloroiodobenzene

: 608131-24-4
Benzhydrylidene-{3-chloro-4-[2-cyclopropyl-2-(4-methoxy-phenylamino)-ethyl]-phenyl}-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / CuI; PPh₃; HN(iPr)2 / (PPh₃)2PdCl₂ / toluene / 6 h / 84 °C

2: Cp₂TiMe₂ / toluene / 24 h / 110 °C

3: 1.20 g / NaBH₃CN; ZnCl₂*Et₂O / diethyl ether; methanol; toluene / 12 h / 25 °C

4: 98 percent / 1,1'-bis(diphenylphosphanyl)ferrocene (DPPF); NaOtBu / Pd₂(dba)3 / toluene / 24 h / 100 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; copper(l) iodide; zinc chloride diethyl ether; sodium cyanoborohydride; diisopropylamine; triphenylphosphine; sodium t-butanolate; bis-triphenylphosphine-palladium(II) chloride; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; dimethyltitanocene; In methanol; diethyl ether; toluene; 1: Sonogashira coupling;
DOI:10.1002/ejoc.200300123

Reference yield:

: 608131-02-8
4-bromo-2-chloro-1-cyclopropylethynyl-benzene

: 608131-24-4
Benzhydrylidene-{3-chloro-4-[2-cyclopropyl-2-(4-methoxy-phenylamino)-ethyl]-phenyl}-amine

Guidance literature:: Multi-step reaction with 3 steps

1: Cp₂TiMe₂ / toluene / 24 h / 110 °C

2: 1.20 g / NaBH₃CN; ZnCl₂*Et₂O / diethyl ether; methanol; toluene / 12 h / 25 °C

3: 98 percent / 1,1'-bis(diphenylphosphanyl)ferrocene (DPPF); NaOtBu / Pd₂(dba)3 / toluene / 24 h / 100 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; zinc chloride diethyl ether; sodium cyanoborohydride; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; dimethyltitanocene; In methanol; diethyl ether; toluene;
DOI:10.1002/ejoc.200300123